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Adenosine Deaminase in Malaria Infection: Effect of 2′-Deoxycoformycin in Vivo

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Purine Metabolism in Man-IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 165))

Abstract

We have observed a dramatic increase in erythrocyte (RBC) adenosine deam;nase (ADA: E.C. 3.5.4.4) activity during malaria infection of the rhesus monkey. Previous studies in our laboratory using P. knowlesi infected rhesus monkeys showed cyclic changes in RBC purine metabolites-particularly ATP and GTP-that were associated with the stage of parasite schizogony (1).

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References

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Author information

Authors and Affiliations

  1. Department of Immunobiology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

    Horace K. Webster

  2. Department of Hematology, Walter Reed Army Institute of Research, Washington, D.C., USA

    William P. Wiesmann & Charles S. Pavia

Authors
  1. Horace K. Webster
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  2. William P. Wiesmann
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  3. Charles S. Pavia
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Editor information

Editors and Affiliations

  1. University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands

    Chris H. M. M. De Bruyn

  2. Guy’s Hospital Medical School, London, UK

    H. Anne Simmonds

  3. University of Vienna, Vienna, Austria

    Mathias M. Müller

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© 1984 Plenum Press, New York

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Webster, H.K., Wiesmann, W.P., Pavia, C.S. (1984). Adenosine Deaminase in Malaria Infection: Effect of 2′-Deoxycoformycin in Vivo . In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4553-4_44

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  • DOI: https://doi.org/10.1007/978-1-4684-4553-4_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4555-8

  • Online ISBN: 978-1-4684-4553-4

  • eBook Packages: Springer Book Archive

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