Abstract
Data linking immunodeficient individuals to a high incidence of malignancy has been collected through the analysis of outcomes in renal allograft recipients (1) and patients with naturally occurring immunodeficiency states such as severe combined immune deficiency (SCID), Wiskott-Aldrich syndr ome (WAS) and ataxia telangiectasia (2–4). The mechanisms involved in the pathogenesis of malignancy in patients with naturally occurring or acquired immunodeficiencies are poorly understood. In large part this is due to the heterogeneity in the scope and severity of immune deficiency in these patients. In addition, some patients are exposed to potentially oncogenic agents, such as Epstein-Barr virus (EBV), that may influence the development of malignancy. Despite the complexity of these patients, certain aspects of the relationship between naturally occurring immune deficiency and malignancy can be studied. Many patients with SCID and WAS have been successfully immunoreconstituted by bone marrow transplantation (BMT). Therefore, it has become possible to ask whether immunoreconstitution prevents the development of malignancy in these patients. This chapter addresses this question by analyzing cases of malignancy in immunodeficient individuals that have undergone either BMT or thymus transplantation. These data will be compared to previously reported cases of malignancies in untransplanted immunodeficient patients.
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References
Penn, I. Malignancies associated with immunosuppressive or cytotoxic therapy. Surgery, 83:294, 1978.
Kersey, J., Spector, B., and Good, R. Primary immunodeficiency diseases and cancer: the Immunodeficiency-Cancer Registry. Int. J. Cancer, 12:333, 1973.
Filipovich, A.H., Zerbe, D., Spector, B., and Kersey, J. Lymphomas in persons with naturally occurring immunodeficiency disorders. In: I.T. Magrath (ed.), The Influence of the Environment on Leukemia and Lymphoma Subtypes. New York: Raven Press, 1983.
Spector, B.D., Perry, G., and Kersey, J.H. Genetically determined immunodeficiency diseases (GDID) and malignancy: report from the Immunodeficiency-Cancer Registry. Clin. Immunol. Immunopathol., 11:12, 1978.
Bortin, M. and Rimm, A. Severe combined immunodeficiency disease. Characterization of the disease and results of transplantation. J. Am. Med. Assoc, 238:591, 1977.
Hong, R. Present and future status of thymus transplantation. Ann. Clin. Res., 13:350, 1981.
Borzy, M.S., Hong, R., Horowitz, S.D., Gilbert, E., Kaurman, D., De Mendonca, W., Oxelius, V.A., Dictor, M., and Pachman, L. Fatal lymphoma after transplantation of cultured thymus in children with combined immunodeficiency disease. N. Engl. J. Med., 301:565, 1979.
Frizzera, G., Rosai, J., Dehner, L., Spector, B.D., and Kersey, J.H. Lymphoreticular disorders in primary immunodeficiencies: new findings based on an up-to-date histologic classification of 35 cases. Cancer, 46:692, 1980.
Kapoor, N., Kirkpatrick, D., Blaese, R., Oleske, J., Hilgartner, M., Changanti, R., Good, R., and O’Reilly, R. Reconstitution of normal megakaryocytopoiesis and immunologic functions in Wiskott-Aldrich syndrome by marrow transplantation following myeloablation and immunosuppression with busulfan and cyclophosphamide. Blood, 57:692, 1981.
Bach, H.F., Albertini, R. J., Joo, P., Anderson, J.L., and Bortin, M.M. Bone marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet, ii:1364, 1968.
August, C.S., Hathaway, W.W., Githens, J.H., Pearlman, D., Mcintosh, K., and Favara, B. Improved platelet function following bone marrow transplantation in an infant with Wiskott-Aldrich syndrome. J. Pediat., 82:58, 1973.
Meuwissen, H.J., Kieserman, E.G., Taft, B., Pollara, B., and Pickering, R.J. Marrow transplantation in Wiskott-Aldrich syndrome: T cell engraftment with cyclophosphamide. Complete engraftment with total body irradiation. Pediat. Res., 12:483, 1978.
Parkman, R., Rappaport, D., Geha, R., Cassady, R., Levey, R., Nathan, D.G., Belli, J., and Rosen, F. Complete correction of the Wiskott-Aldrich syndrome by allogeneic bone marrow transplantation. N. Engl. J. Med., 298:921, 1978.
Hanto, D., Sakamoto, K., Purtilo, D.T., Simmons, R., and Najarian, J. The Epstein-Barr virus in the pathogenesis of post transplant lymphoproliferative disorders. Surgery, 90:204, 1981.
Thestrup-Pedersen, K., Esmann, V., Jensen, J.R., Hastrup, J., Thorling, K., Saemundsen, A.K., Bisballe, S., Oallesen, G., Madsen, M., Grazia-Masucci, M., and Emberg, I. Epstein-Barr virus-induced lymphoproliferative disorder converting to fatal Burkitt-like lymphoma in a boy with interferon inducible chromosomal defect. Lancet, ii:997, 1980.
Taylor, A., Harnden, D., Arlett, C., Harcourt, S., Lehmann, A., Stevens, S., and Bridges, B. Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature, 258:427, 1975.
Filipovich, A.H. and Spector, B.D. Immunodeficiency (ID) as a susceptibility factor for malignancy in ataxia telangiectasia (AT): report from the Immunodeficiency-Cancer Registry (ICR). Pediat. Res., 15(4):806, 1981.
Tsoi, M. Immunological mechanisms of graft-versus-host disease in man. Transplantation, 33:459, 1982.
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Neudorf, S.M.L., Filipovich, A.H., Kersey, J.H. (1984). Immunoreconstitution by Bone Marrow Transplantation Decreases Lymphoproliferative Malignancies in Wiskott-Aldrich and Severe Combined Immune Deficiency Syndromes. In: Purtilo, D.T. (eds) Immune Deficiency and Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4760-6_24
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DOI: https://doi.org/10.1007/978-1-4684-4760-6_24
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