Abstract
The effect of vitamin D3 and of its biologically most active metabolite, 1,25-dihydroxyvifamin D3, on intestinal calcium and inorganic phosphate (Pi) absorptive mechanisms has been studied extensively in an organ culture system of embryonic chick small intestine (Corradino, 1973; Peterlik, 1978; Cross and Peterlik, 1982). Elevation of Ca and Pi uptake by vitamin D depends on prior gene activation by the sterol (cf. also Franceschi and DeLuca, 1981b). However, this vitamin D action is only partially expressed in undifferentiated absorptive cells, since they respond to the sterol solely by an increase in Ca but not in Pi uptake. Induction of the latter has been shown to require advanced target cell maturation (Cross and Peterlik, 1982).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Berner, W., Kinne, R., and Murer, H.: Phosphate Transport into Brush-Border Membrane Vesicles Isolated from Rat Small Intestine. Biochem.J. 160: 467–474 (1976).
Birge, S.J., and Alpers, D.H.: Stimulation of Intestinal Mucosal Proliferation by Vitamin D. Gastroenterol. 64: 977–982 (1973).
Charney, A.N., Gots, R.E., and Gianella, R.A.: (Na+-K+)-Stimulated Adenosine Triphosphatase in Isolated Intestinal Villus Tip and Crypt Cells. Biochim.Biophys.Acta 367: 265–270 (1974).
Corradino, R.A.: Embryonic chick intestine in organ culture: A unique system for the study of the intestinal calcium absorptive mechanism. J.Cell Biol. 58: 64–78 (1973).
Corradino, R.A.: A Simple Technique for the Measurement of Unidirectional Calcium Influx at the Mucosal Surface of Organ-Cultured Embryonic Chick Duodenum. Analyt.Biochem. 91: 60–69 (1978).
Cross, H.S., and Peterlik, M.: Differential Response of Enterocytes to Vitamin D during Embryonic Development: Induction of Intestinal Inorganic Phosphate, D-Glucose and Calcium Uptake. Horm.metabol.Res. 14: 649–652 (1982).
Franceschi, R.T., and De Luca, H.F.: Characterization of 1,25-Dihydroxyvitamin D3-dependent Calcium Uptake in Cultured Embryonic Chick Duodenum. J.Biol.Chem. 256: 3840–3847 (1981a).
Franceschi, R.T., and De Luca, H.F.: The effect of inhibitors of protein and RNA synthesis on la,25-dihydroxyvitamin D3-dependent calcium uptake in cultured embryonic chick duodenum. J.Biol.Chem. 256: 3848–3852 (1981b).
Fuchs, R., and Peterlik, M.: Vitamin D-Induced Phosphate Transport in Intestinal Brush Border Membrane Vesicles. Biochem. Biophys.Res.Comm. 93: 87–92 (1980).
Hildmann, B., Schmidt, A., and Murer, H.: Ca++-Transport across Basal-Lateral Plasma Membranes from Rat Small Intestinal Epithelial Cells. J.Membrane Biol. 65: 55–62 (1982).
Peterlik, M.: Phosphate transport by embryonic chick duodenum: Stimulation by vitamin D3. Biochim.Biophys.Acta 514: 164–171 (1978).
Peterlik, M., Fuchs, R., and Cross, H.S.: Stimulation of D-glucose transport. A novel effect of vitamin D on intestinal membrane transport. Biochim.Biophys.Acta 649: 138–142 (1981).
Rozengurt, E., and Mendoza, S.: Monovalent Ion Fluxes and the Control of Cell Proliferation in Cultured Fibroblasts. Ann.N.Y. Acad.Sci. 339: 175–190 (1980).
Schultz, S.G.: Transport Across Small Intestine, in: “Membrane Transport in Biology” Vol. IVB, Giebisch, G., Tosteson, D.C., Ussing, H.H., eds., Springer Verlag New York (1979).
Wasserman, R.H.: Intestinal absorption of calcium and phosphorus. Fed.Proc. 40: 68–72 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Cross, H.S., Peterlik, M. (1984). Vitamin D Activates (Na+-K+)ATPase: A Possible Regulation of Phosphate and Calcium Uptake by Cultured Embryonic Chick Small Intestine. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_24
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4808-5_24
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4810-8
Online ISBN: 978-1-4684-4808-5
eBook Packages: Springer Book Archive