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Calcium Absorption in the Rat Colon Measured in Vivo

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Phosphate and Mineral Homeostasis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 208))

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Abstract

Calcium absorption in the large intestine was studied under physiological conditions in the rat. When 45Ca was administered directly into the caecum, the isotope was significantly absorbed. This absorption was modulated by dietary Ca and Pi as well as by the 1,25 (OH)2 D3 status. On the other hand, calcium coming from the food, either as 45Ca or as 45Ca, was not absorbed to a significant amount. When the absorption of 45Ca from the caecal content was assessed in duodenal loops, less 45Ca was absorbed when the isotope was administered orally than when it was added to the caecal content. Thus, the fact that oral Ca is not absorbed in the colon despite the efficient Ca transport system of this part of the intestine may be due to the transformation in the digestive tract of Ca from an absorbable into a non-absorbable form.

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References

  1. Bonjour, J.-P., H. Fleisch, and U. Trechsel. Calcium absorption in diphosphonate-treated rats: effect of parathyroid function, dietary calcium and phosphorus. J. Physiol. 264: 125–139, 1977.

    Google Scholar 

  2. Favus, M.J., S.C. Kathpalia, F.L. Coe, and A.E. Mond. Effects of diet calcium and 1,25-dihydroxyvitamin D on colon calcium active transport. Am. J. Physiol. 238: G75 - G78, 1980.

    Google Scholar 

  3. Favus, M.J., M. Berelowitz, and F.L. Coe. Effects of somatostatin on intestinal calcium transport in the rat. Am. J. Physiol. 241: G215 - G221, 1981.

    Google Scholar 

  4. Grinstead, W.C., C.Y.C. Pak, and G.J. Krejs. Effect of 1,25-dihydroxyvitamin D3 on calcium absorption in the colon of healthy humans. Am. J. Physiol. 247: G189–G192, 1984.

    Google Scholar 

  5. Harrison, H.C., and H.E. Harrison. Calcium transport by rat colon in vitro. Am. J. Physiol. 217: 121–125, 1969.

    Google Scholar 

  6. Hylander, E., K. Ladefoged, and S. Jarnum. The importance of the colon in calcium absorption following small-intestine resection. Scand. J. Gastroenterol. 15: 55–60, 1980.

    Google Scholar 

  7. Lee, D.B.N., W. Walling, U. Gafter, V. Silis, and J.W. Coburn. Calcium and inorganic phosphate transport in rat colon. Dissociated response to 1,25-dihydroxyvitamin D3. J. Clin. Invest. 65:13261331, 1980.

    Google Scholar 

  8. Mainoya, J.R. Effects of bovine growth hormone, human placental lactogen and ovine prolactin on intestinal fluid and ion transport in the rat. Endocrinology 96: 1165–1170, 1975.

    Google Scholar 

  9. Nellans, H.N., and R.S. Goldsmith. Transepithelial calcium transport by rat cecum: high-efficiency absorptive site. Am. J. Physiol. 240:G424–G431, 1981

    Google Scholar 

  10. Petith, M.M., and H.P. Schedl. Intestinal adaptation to dietary calcium restriction: in vivo cecal and colonic calcium transport in the rat. Gastroenterology 71: 1039–1042, 1976.

    Google Scholar 

  11. Petith, M.M., H.D. Wilson, and H.P. Schedi. Vitamin D dependence of in vivo calcium transport and mucosal calcium binding protein in rat large intestine. Gastroenterology 76 (1): 99–104, 1979.

    Google Scholar 

  12. Rizzoli, R., H. Fleisch, and J.-P. Bonjour. Effect of thyroparathyroidectomy on calcium metabolism in rats: role of 1,25-dihydroxyvitamin D3. Am. J. Physiol. 233: E160–E164, 1977.

    Google Scholar 

  13. Rizzoli, R., H. Fleisch, and J.-P. Bonjour. Role of 1,25-dihydroxyvitamin D on intestinal phosphate absorption in rats with a normal vit3amin D supply. J. Clin. Invest. 60:639–647, 1977.

    Google Scholar 

  14. Trechsel, U., C.M. Taylor, J.A. Eisman, J.-P. Bonjour, and H. Fleisch. Plasma levels of vitamin D metabolites in diphosphonate-treated rats. Clin. Sci. 61: 471–476, 1981.

    Google Scholar 

  15. Wasserman, R.H. Vitamin D and the absorption of calcium and strontium in vivo. In The Transfer of Calcium and Strontium Across Biological Membranes. R.H. Wasserman, editor. Academic Press, New York. 1963, pp. 211–228.

    Google Scholar 

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© 1986 Plenum Press, New York

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Ammann, P., Rizzoli, R., Fleisch, H. (1986). Calcium Absorption in the Rat Colon Measured in Vivo. In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_29

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  • DOI: https://doi.org/10.1007/978-1-4684-5206-8_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5208-2

  • Online ISBN: 978-1-4684-5206-8

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