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Bronchopulmonary Pharmacology of PAF-Acether

  • Chapter
Platelet-Activating Factor and Related Lipid Mediators

Abstract

Guinea pigs undergo BC when injected with direct smooth muscle stimulating substances (histamine, serotonin, acetylcholine) or with agents that trigger the release or the formation of endogenous mediators (stored histamine or serotonin, kinins, complement factors, arachidonate metabolites). A few mediators (bra-dykinin, histamine) act directly on smooth muscle and trigger as well the release of arachidonate, which is then converted into cyclooxygenase and lipoxygenase metabolites. Platelet-stimulating agents such as collagen (Vargaftig et al., 1979), ADP and ATP (Lefort and Vargaftig, 1978), and PAF-acether (Vargaftig et al., 1980a,b, 1981a) induce BC because they stimulate platelets to release bronchoactive substances and, accordingly, BC is suppressed by platelet depletion or protection with prostacyclin.

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Authors and Affiliations

  1. Pasteur Institute, Paris, France

    B. Boris Vargaftig

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  1. B. Boris Vargaftig
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Editors and Affiliations

  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder Ph.D

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© 1987 Plenum Press, New York

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Vargaftig, B.B. (1987). Bronchopulmonary Pharmacology of PAF-Acether. In: Snyder, F. (eds) Platelet-Activating Factor and Related Lipid Mediators. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5284-6_16

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  • DOI: https://doi.org/10.1007/978-1-4684-5284-6_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5286-0

  • Online ISBN: 978-1-4684-5284-6

  • eBook Packages: Springer Book Archive

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