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Effect of PAF on the Cardiovascular System

  • Chapter
Platelet-Activating Factor and Related Lipid Mediators

Abstract

The term platelet-activating factor (PAF) proposed by Benveniste et al. (1972) was originally designed to indicate the primary biological properties of a novel substance released from basophils upon IgE stimulation. This factor was later identified independently by three separate groups (Benveniste et al., 1979; Blank et al., 1979; Demopoulos et al., 1979) to be l-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine. This novel group of compounds was rapidly recognized to have diverse biological actions, far beyond those originally shown on platelets. It also became apparent that PAF can be synthesized and released from a multitude of cells and organs by immune and nonimmune stimuli (Benveniste and Chignard, 1985; Snyder, 1985; Vanhoutte and Houston, 1985; Zimmerman et al., 1985).

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Authors and Affiliations

  1. Neurobiology Research Division, Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814-4799, USA

    Giora Feuerstein

  2. Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814-4799, USA

    Robert E. Goldstein

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  1. Giora Feuerstein
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  2. Robert E. Goldstein
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Editors and Affiliations

  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder Ph.D

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© 1987 Plenum Press, New York

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Feuerstein, G., Goldstein, R.E. (1987). Effect of PAF on the Cardiovascular System. In: Snyder, F. (eds) Platelet-Activating Factor and Related Lipid Mediators. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5284-6_19

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