A Predominant Idiotype in the Gut Associated Lymphoid Tissue

Andre, P. M.; Tomasi, T. B.

doi:10.1007/978-1-4684-5344-7_19

P. M. Andre^4,5 &
T. B. Tomasi^4,5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 216 A))

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Abstract

A high percentage of gut lamina propria plasma cells in tissue sections were stained by three fluoresceinated rabbit anti mouse IgG3 antisera. Similar cytoplasmic staining was found in several mouse strains including CBA/N mice. To further extend these data, northern hybridization experiments with a cDNA probe specific for IgG3 was performed with total RNA isolated from the small intestine or from cell preparations enriched for lamina propria plasma cells (data not shown). In contrast to the fluorescent studies, little or no mRNA for IgG3 was found. In all cases the antigen used in producing the anti-mouse IgG3 serum was the J 606 (IgG3) myeloma protein, which reacts with certain polysaccharides such as inulin [β(2–1) poly fructosan] and bacterial levan [β(2–6) polyfructosan].

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Authors and Affiliations

Laboratoire de Microbiology, Faculte de Medecine, Rennes, France and Department of Cell Biology, University of New Mexico, Albuquerque, New Mexico, USA
P. M. Andre & T. B. Tomasi
Roswell Park Memorial Institute, Buffalo, New York, USA
P. M. Andre & T. B. Tomasi

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P. M. Andre
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T. B. Tomasi
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Editors and Affiliations

University of Alabama at Birmingham, Birmingham, Alabama, USA
Jiri Mestecky & Jerry R. McGhee &
McMaster University, Hamilton, Ontario, Canada
John Bienenstock
State University of New York at Buffalo, Buffalo, New York, USA
Pearay L. Ogra

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Andre, P.M., Tomasi, T.B. (1987). A Predominant Idiotype in the Gut Associated Lymphoid Tissue. In: Mestecky, J., McGhee, J.R., Bienenstock, J., Ogra, P.L. (eds) Recent Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 216 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5344-7_19

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DOI: https://doi.org/10.1007/978-1-4684-5344-7_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5346-1
Online ISBN: 978-1-4684-5344-7
eBook Packages: Springer Book Archive

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