Abstract
It is a classical feature that the denervation of the neuromuscular junction induces a supersensitivity of the cholinergic post-synaptic receptors (Cannon & Rosenblueth, 1949). In the central nervous system, the development of this “denervation supersensitivity” is more complex. In fact, in some cases, even the total destruction of an homogeneous population of afferent presynaptic fibers may not produce an hypersensitivity of the corresponding post-synaptic receptors (Von Voigtlander et al., 1973; Tassin et al., 1982). This suggests that the affinity or the number of postsynaptic receptor sites is not only regulated by chemical signals from presynaptic fibers but also by those delivered by some other neuronal inputs to the target cells.
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Tassin, J.P., Hervé, D., Simon, H., Taghzouti, K., Le Moal, M., Glowinski, J. (1987). Long-term Receptor Regulation Induced by Denervation of Heterologous Afferent Fibers: Functional Significance. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5415-4_21
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DOI: https://doi.org/10.1007/978-1-4684-5415-4_21
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