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The Respiratory Burst and the NADPH Oxidase of Phagocytic Leukocytes

  • Chapter
The Respiratory Burst and Its Physiological Significance

Abstract

When phagocytic leukocytes are activated to kill microorganisms, these cells respond with considerable changes in their cellular metabolism and structure.1 Most marked is a 20- to 30-fold increase in the oxygen consumption (i.e., the respiratory burst) that is not sensitive to inhibitors of the mitochondrial respiration.2 The extra oxygen consumption reflects the action of a phagocyte-specific oxidase, responsible for the generation of reduced oxygen species.1 This enzyme is localized in the plasma membrane and—after phagocytosis—in the phagosomal membranes of the cell.3,4

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Authors and Affiliations

  1. Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory of Experimental and Clinical Immunology, University of Amsterdam, 1006 AK, Amsterdam, The Netherlands

    Dirk Roos, René Lutter & Ben G. J. M. Bolscher

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  1. Dirk Roos
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  2. René Lutter
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  3. Ben G. J. M. Bolscher
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  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Clinical Pathology Facility, Inc., Pittsburgh, Pennsylvania, USA

    Robert R. Strauss

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© 1988 Plenum Press, New York

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Roos, D., Lutter, R., Bolscher, B.G.J.M. (1988). The Respiratory Burst and the NADPH Oxidase of Phagocytic Leukocytes. In: Sbarra, A.J., Strauss, R.R. (eds) The Respiratory Burst and Its Physiological Significance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5496-3_3

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