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Comparison of Growth Effects of rhIGF-l in Diabetic and Hypox Rats with those of Insulin and Growth Hormone

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Basic and Clinical Aspects of Growth Hormone

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

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Abstract

Insulin-like growth factor I (IGF-I) stimulates replication of cultured cells in vitro (1–3). In contrast to other growth factors, IGF-I does not lead to dedifferentiation of differentiated cells in culture, but rather maintains or even enhances the degree of differentiation of cultured cells (2,4,5). In view of (1) these in vitro findings, (2) the similarity of action between insulin and IGF-I on differentiation (2–5), and (3) several reports on growth stimulation by IGF-I in hypox and other animals (6–8), we decided to investigate the action of recombinant human IGF-I (rhIGF-I) on diabetic and hypophysectomized rats. In addition, acute effects of IGF yere studied in man (9,10).

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Authors and Affiliations

  1. Metabolic Unit, Department of Medicine, University of Zurich, Zurich, Switzerland

    E. R. Froesch, H. P. Guler, M. Ernst, C. Schmid, E. Scheiwiller & J. Zapf

Authors
  1. E. R. Froesch
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  2. H. P. Guler
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  3. M. Ernst
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  4. C. Schmid
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  5. E. Scheiwiller
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  6. J. Zapf
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Barry B. Bercu

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© 1988 Plenum Press, New York

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Froesch, E.R., Guler, H.P., Ernst, M., Schmid, C., Scheiwiller, E., Zapf, J. (1988). Comparison of Growth Effects of rhIGF-l in Diabetic and Hypox Rats with those of Insulin and Growth Hormone. In: Bercu, B.B. (eds) Basic and Clinical Aspects of Growth Hormone. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5505-2_19

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  • DOI: https://doi.org/10.1007/978-1-4684-5505-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5507-6

  • Online ISBN: 978-1-4684-5505-2

  • eBook Packages: Springer Book Archive

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