Abstract
Amongst potential novel intraovarian regulators, insulin-like growth factor I (IGF-I) has been the subject of increasingly intense investigation1. Taken together, these studies strongly suggest the existence of an intraovarian autocrine control mechanism, wherein IGF-I may serve as the central signal, and the granulosa cell its site of production, reception, and action. In doing so, IGF-I may promote the replication and/or cytodifferentiation of the developing granulosa cell, acting largely (but not exclusively) as an amplifier of gonadotropin action. Furthermore, IGF-I (presumptively of granulosa cell origin) may also provide paracrine input to the adjacent theca-interstitial cell compartment in the interest of coordinated follicular development.
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E.Y. Adashi, C.E. Resnick, A.J. D’Ercole, M.E. Svoboda, and J.J. Van Wyk, 1985, Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function, Endocr Rev 6:400–420, (1985).
J.M. Hammond, Peptide regulators in the ovarian follicle, Austr J Biol Sci 34:491 (1981).
C.J. Hsu and J.M. Hammond, Gonadotropins and estradiol stimulate immunoreactive insulin-like growth factor-I production by porcine granulosa cells in vitro, Endocrinology 120:198 (1987).
J.M. Hammond, J.L.S. Baranao, D. Skaleris, A.B. Knight, J.A. Romanus, and M.M. Rechler, Production of insulin-like growth factors by ovarian granulosa cells, Endocrinology 117:2553 (1985).
J.B. Davoren, B.G. Kasson, C.H. Li, and A.J.W. Hsueh, Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: relation to IGF action, Endocrinology 119:2155 (1986).
E.R. Hernandez, E. Hoyt, J.J. Van Wyk, E.Y. Adashi, The somatomedin-C insulin-like growth factor I (Sm-C/IGF-I) gene is expressed in the rat ovary, Presented at the 69th Annual Meeting of the Endocrine Society, Indianapolis, IN (Abstract #821) (1987).
L.H. Murphy, G.I. Bell, and H.G. Friesen, Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat, Endocrinology 120:1279 (1987).
R. Voutilainen, and W.L. Miller, Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-clevage enzyme, P450ssc, in human steroidogenic tissues, Pro Natl Acad Sci, USA 84:1590 (1987).
R. Homburg, A. Eshel, I Abdalla, and H.S. Jacobs, Growth hormone facilitates ovulation induction by gonadotropins, Clin Endocrinol 29:113–117 (1988).
J.L.S. Baranao and J.M. Hammond, Comparative effects of insulin and insulin-like growth factors on DNA synthesis and differentiation of porcine granulosa cells, Biochem Biophys Res Commun 124:484 (1984).
J.D. Veldhuis, R.W. Furlanetto, D. Juchter, J. Garmey and P. Veldhuis, Trophic actions of human somatomedin-C/insulin-like growth factor I on ovarian cells: in vitro studies with swine granulosa cells, Endocrinology 116:1235 (1985).
E.Y. Adashi, C.E. Resnick, E.R. Hernandez, M.E. Svoboda, and J.J. Van Wyk, Characterization and regulation of a specific cell membrane receptor for somatomedin-C/Insulin-like growth factor I in cultured rat granulosa cells, Endocrinology 122:194–201 (1987).
E.Y. Adashi, C.E. Resnick, M.E. Svoboda, and J.J. Van Wyk, Follicle-stimulating hormone enhances somatomedin-C binding to cultured rat granulosa cells: evidence for cAMP-dependence, J of Bio Chem 261:3923–3926 (1986).
E.Y. Adashi, C.E. Resnick, M.E. Svoboda, J.J. Van Wyk, V.C Hascall, M. Yanagishita, Independent and synergistic actions of somatomedin-C in the stimulation of proteoglycan biosynthesis by cultured rat granulosa cells, Endocrinology 118:456 (1986).
E.Y. Adashi, C.E. Resnick, J.V. May, M. Knecht, M.E. Svoboda, and J.J. Van Wyk, Somatomedin-C/Insulin like growth factor I as an amplifier of follicle-stimulating hormone action: studies on mechanism(s) and site(s) of action incultured rat granulosa cells, Endocrinology 122:1583–1592 (1987).
J.V. May, D.W. Schomberg, S. Gordon, A. Amsterdam, Synergistic effect of insulin and follicle-stimulating hormone on biochemical and morphological differentiation of porcine granulosa cells, Biol Reprod 32:(Suppl) 53 (1985).
E.R. Hernandez, C.E. Resnick, M.E. Svoboda, J.J. Van Wyk, D.W. Payne, E.Y. Adashi, Somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) as an enhancer of androgen biosynthesis by cultured rat ovarian cells, Endocrinology 122:1583–1592 (1987).
J.A. Eden, J. Jones, G.D. Carter, and J. Alaghband-Zadeh, A comparison of follicular fluid levels of insulin-like growth factor-1 in normal dominant and cohort follicles, polycystic and multicystic ovaries, Clin Endocrinol 29:327–336 (1988).
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© 1989 Plenum Press, New York
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Adashi, E.Y., Resnick, C.E., Hernandez, E.R., Svoboda, M.E., Van Wyk, J.J. (1989). Ovarian Insulin-Like Growth Factor I: Basic Concepts Leading to Potential Clinical Outlets. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_13
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DOI: https://doi.org/10.1007/978-1-4684-5685-1_13
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