Skip to main content

Abnormal Susceptibility to Lipid Peroxidation of Plasma LDL and Its Prevention by α-Tocopherol During Experimental Cholestasis in the Rat

  • Chapter
Antioxidants in Therapy and Preventive Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

Thiobarbituric acid reactive substances (TBARS) represent an helpful index of lipid peroxidation in erythrocytes and lipoproteins (1) .Peroxidation is depending on the status of the antioxidant protecting system including the vitamin E tissue level(2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. l)K.,Yagi,Assay for serum lipid peroxide level and its clinical significance in :“Lipid peroxides in biology and medicine”,K.Yagi,ed.Academic Press.1980.

    Google Scholar 

  2. M.Miki,H.Tamai,M.Mino,Y.Yamamoto,and E.Niki,Free radicals chain oxidation of rat red blood cells by molecular oxygen and its inhibition by a-tocopherol,Arch.Biochem.BiophyS,258:373–389,1987.

    Article  PubMed  CAS  Google Scholar 

  3. D.Seidel,P.Alaupovic,R.H.Furman,A lipoprotein characterizing obstructive jaundice.I.Method for quantitative separation and identification of lipoproteins in jaundiced subjects,J.Clin.Invest.48,1211–1223,1969.

    Article  PubMed  CAS  Google Scholar 

  4. J.Picard,D.Veissiere,Abnormal serum lipoprotein in cholestasis identification and isolation,Clin.Chim.Acta,30,149–154,1970.

    Article  PubMed  CAS  Google Scholar 

  5. K.M.Brinkhous,E.D.Warner,Muscular dystrophy in biliary fistula dogs Possible relationship to vitamin E deficiency,Am. J.Pathol,98:81–86,1941.

    Google Scholar 

  6. V.G.Levy,“Cirrhose biliaire primitive de l’adulte”,in“Précis des maladies du foie”,J.Caroli,A,Ribet,A.,Paraf,ed Masson,Paris 1975.

    Google Scholar 

  7. A. M.Fogelman,I.Shechter,J.Saeger,M.Hokom,J.S.Child,P.A.Edward, Malondialdehyde alteration of low density lipoproteins leads to cholesteryl esters accumulation in human monocytes-macrophages, Proc,Natl,Acad,Sei USA 79:1712–1716,1980.

    Google Scholar 

  8. L.G.Alcindor,H.Aalam,J.Masliah,G.Thomas-Benhamou, M.Ouka,M-C.Piot,Le rapport de concentration molaire cholesterol sur phospholipides des LDL dans les hépatopathies,Méd.Chir.Dig. 10,673–674,1981.

    PubMed  CAS  Google Scholar 

  9. M.Goudard,C.Aubry,L.G.Alcindor,Etude d’un raéctif précipitant sélectivement les LDL.Vème Colloque international de Biologie Prospective .Ann.Biol .Clin., 40:466,1982.

    Google Scholar 

  10. L.G.Alcindor,M.Fadel-Khadra ,H.Antebi,M.C.Piot,M.J.Guerrito,Y.Giudicelli ,R.Nordmann,A rapid assay for cholesterol and phospholipids in erythrocyte membranes ,Ann .Biol.Clin.46:586,1988.

    Google Scholar 

  11. L.G.Alcindor,H.Antebi,L.De Paillette, L.Malagrida, D.Hillion , Y.Giudicelli,MDA des membranes erythrocytaires et LDL-MDA au cours de l’épuration extra-renale, Ann.Biol.Clin, 46,537,1988.

    Google Scholar 

  12. H.Ohkawa,N.Ohishi and K.Yagi,Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,Anal.Biochem 95:351–358,1979.

    Article  PubMed  CAS  Google Scholar 

  13. J.S.Owen,R.A.Hutton,M.J.Hope,D.S.Harry,K.R.Bruckdorfer,R.C.Day,N.McIntyre and J.A.Lucy,Lecithin:Cholesterol acyltransferase deficiency and cell membran( lipids and function in human liver disease Scand.J.Clin.Lab.Invest.38,suppl. 150:228–232,1978.

    Article  CAS  Google Scholar 

  14. D.Steinberg,“Metabolism of lipoproteins and their role in the pathogenesis of atherosclerosis” in:Atherosclerosis Reviews,vol 18,J.Stokes III and M. Mancini ed,Raven Press limited New-York,1988.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Alcindor, L.G., Antebi, H., Fadel-Khadra, M., Piot, MC., Giudicelli, Y., Nordmann, R. (1990). Abnormal Susceptibility to Lipid Peroxidation of Plasma LDL and Its Prevention by α-Tocopherol During Experimental Cholestasis in the Rat. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5730-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5732-2

  • Online ISBN: 978-1-4684-5730-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics