Skip to main content
SpringerLink
Log in

Differences in the Effects of Acute and Chronic Administration of Dexfenfluramine on Cortisol and Prolactin Secretion

  • Chapter
Circulating Regulatory Factors and Neuroendocrine Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 274))

Abstract

The involvement of serotonin on neuroendocrine regulation has been substantiated by much experimental data. Indeed, serotonin has been shown to play a role in the regulation of pituitary hormones that display a secretory rhythmicity and/or changes after exposure by to various types of stress. These results are supported by the existence of a serotoninergic innervation of hypothalamic regions that control hormonal rhythmical secretion of hormones (suprachiasmatic nucleus) and that respond to stress (paraventricular nucleus) (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Montange, M., and A. Calas, Serotonin and endocrinology, the pituitary, In N.N. Osborn and M. Hamon (eds) Neuronal Serotonin ,Wiley & Sons, New York, pp. 271–303, 1988.

    Google Scholar 

  2. Kyriakides, M., and T. Silverstone, Comparison of the effects of d-amphetamine and fenfluramine on hunger and food intake in man, Neuropharmacology 18: 1007–1008, 1979.

    Article  PubMed  CAS  Google Scholar 

  3. Wurtman, J.J., and R.J. Wurtman, D-fenfluramine selectively decreases carbohydrate but not protein intake in obese subjects, Int J Obes 8: 79–84, 1984.

    PubMed  Google Scholar 

  4. Garattini, S., W. Buczo, A. Jori, and R. Samanin, The mechanism of action of fenfluramine, Postgrad Med J 15: 27–35, 1975.

    Google Scholar 

  5. Leibowitz, S.F., G.F. Weiss, and G. Shor-Posner, Hypothalamic serotonin: pharmacological, biochemical, and behavioral analyses of its feed-suppressive action, Clin Neuropharmacol 11: S51–S71, 1988.

    PubMed  CAS  Google Scholar 

  6. Kiss, J.Z., Dynamism of chemoarchitecture in the hypothalamic paraventricular nucleus, Brain Res Bull 20: 699–708, 1988.

    Article  PubMed  CAS  Google Scholar 

  7. Fuller, R.W., and H.D. Snoddy, Effect of serotonin-releasing drugs on serum corticosterone in rats, Neuroendocrinology 31: 96–100, 1980.

    Article  PubMed  CAS  Google Scholar 

  8. Koenig, J.I., G.A. Gudelsky, and H.Y. Meltzer, Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation, Eur J Pharmacol 137: 1–8, 1987.

    Article  PubMed  CAS  Google Scholar 

  9. Lipolists, Zs., C. Phelix, and W.K. Pauli, Synaptic interaction of serotonergic axons and corticotropin-releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the rat, Histochemistry 86: 541–549, 1987.

    Article  Google Scholar 

  10. Feldman, S., N. Conforti, and E. Melamed, Paraventricular nucleus serotonin mediates neurally stimulated adrenocortical secretion, Brain Res Bull 18: 165–168, 1987.

    Article  PubMed  CAS  Google Scholar 

  11. Van de Kar, L.D., J.H. Urban, K.D. Richardson, and C.L. Bethea, Pharmacological studies on the serotoninergic and nonserotonin-mediated stimulation of prolactin and corticosterone secretion by fenfluramine. Effects of pretreatment with fluoxetine, indalpine, PCPA, and L-tryptophan, Neuroendocrinology 41: 283–288, 1985.

    Google Scholar 

  12. McElroy, J.F., J.M. Miller, and J.S. Meyer, Fenfluramine, p-chloroamphetamine and p-fluoroamphetamine stimulation of pituitary-adrenocortical activity in rat: evidence for differences in site and mechanism of action, J Pharmacol Exper Ther 228: 593–599, 1984.

    CAS  Google Scholar 

  13. Porter, J.C., and K.R. Smith, Collection of hypophysial stalk blood in rat, Endocriology 81: 1182–1185, 1967.

    Article  CAS  Google Scholar 

  14. Ježová, D., R. Kvetňanský, K. Kovács, Z. Opršalová, M. Vigaš, and G.B. Makara, Insulin-induced hypoglycemia activates the release of adrenocorticotropin predominantly via central and propranolol insensitive mechanisms, Endocrinology 120: 409–415, 1987.

    Article  PubMed  Google Scholar 

  15. Rowland, N.E., Effect of continuous infusions of dexfenfluramine on food intake, body weight and brain amines in rats, Life Sci 39: 2581–2586, 1986.

    Article  PubMed  CAS  Google Scholar 

  16. Guillaume, V., B. Conte-Devolx, A. Szafarczyk, F. Malaval, N. Pares-Herbut, M. Grino, G. Alonso, I. Assenmacher, and C. Oliver, The corticotropin-releasing factor release in rat hypophysial portal blood is mediated by brain catecholamines, Neuroendocrinology 46: 143–146, 1987.

    Article  PubMed  CAS  Google Scholar 

  17. Conte-Devolx, B., C. Oliver, P. Giraud, E. Castanas, F. Boudouresque, P. Gillioz, and Y. Millet, Adrenocorticotropin, β-endorphin and corticosterone secretion in Brattleboro rats, Endocrinology 110: 2097–2100, 1982.

    Article  PubMed  CAS  Google Scholar 

  18. Gibbs, D.M., and W. Vale, Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood, Brain Res 280: 176–179, 1983.

    Article  PubMed  CAS  Google Scholar 

  19. Holmes, M.C., G. Di Renzo, U. Beckford, B. Gillham, and M.T. Jones, Role of serotonin in the control of secretion of corticotrophin releasing factor, J Endocrinol 93: 151–160, 1982.

    Article  PubMed  CAS  Google Scholar 

  20. Garattini S., S. Caccia, T. Mennini, R. Samanin, S. Consolo, and H. Ladinsky, Biochemical pharmacology of the anorectic drug fenfluramine: a review, Curr Med Res Opin 6: 15–27, 1979.

    Article  CAS  Google Scholar 

  21. Schwartz, D., L. Hernandez, and B.G. Hoebel, Fenfluramine administered systematically or locally increases extracellular serotonin in lateral hypothalamus as measured by microdialysis, Brain Res 482: 261–270, 1989.

    Article  PubMed  CAS  Google Scholar 

  22. Heybach, J.P., and J. Vernikos-Danellis, Effects of fenfluramine administration on activity of the pituitary-adrenal system in the rat, West Pharmacol Soc Proc 21: 19–25, 1978.

    CAS  Google Scholar 

  23. Van de Kar, L.D., C.W. Wilkinson, Y. Skrobik, M.S. Brownfield, and W.F. Ganong, Evidence that serotonergic neurons in the dorsal raphe nucleus exert a stimulatory effect on the secretion of renin but not of corticosterone, Brain Res 235: 233–243, 1982.

    Article  PubMed  Google Scholar 

  24. Van de Kar, L.D., C.W. Wilkinson, and W.F. Ganong, Pharmacological evidence for a role of brain serotonin in the maintenance of plasma renin activity in unanesthetized rats, J Pharmacol Exper Ther 219: 85–90, 1981.

    Google Scholar 

  25. Verhofstad, A.A.J., and G. Jonsson, Immunohistochemical and neurochemical evidence for the presence of serotonin in the adrenal medulla of the rat, Neuroscience 10: 1443–1453, 1983.

    Article  PubMed  CAS  Google Scholar 

  26. Rácz, K., I. Wolf, R. Kiss, G. Lada, S. Vida, and E. Gláz, Corticosteroidogenesis by insolated human adrenal cells: effect of serotonin and serotonin antagonists, Experientia 35: 1532–1535, 1979.

    Article  PubMed  Google Scholar 

  27. Serri, O, and E. Rasio, Effect of chronic administration of dextrofenfluramine (d-F) on prolactin (PRL) and corticosterone secretion and on central dopaminergic receptors, 70thAnnual Meeting of the Endocrine Society ,New Orleans, LA, June, Abstract 1177, p. 315, 1988.

    Google Scholar 

  28. Brindley, D.N. Metabolic and hormonal effects of dexfenfluramine on stress stiuations, Clin Neuropharmacol [Suppl 11] 1: S86–S89, 1988.

    Google Scholar 

  29. Yehuda, R., and J.S. Meyer, A role for serotonin in the hypothalamic-pituitary-adrenal response to insulin stress, Neuroendocrinology 38: 25–32, 1984.

    Article  PubMed  CAS  Google Scholar 

  30. Szafarczyk, A., G. Ixart, F. Malaval, J. Nouguier-Soule, and I. Assenmacher, Effects of lesions of the suprachiasmatic nuclei and of p-chlorophenylalanine on the circadian rhythms of adrenocorticotrophic hormone and corticosterone in the plasma and on locomotor activity of rats, J Endocrinol 83:1–16,1979.

    Article  PubMed  CAS  Google Scholar 

  31. Kopelman, P.G., Neuroendocrine function in obesity, Clin Endocrinol 28: 675–689, 1988.

    CAS  Google Scholar 

  32. Bernini, G.P., G.F. Argenio, M.S. Vivaldi, C. Del Corso, M. Sgro, F. Franchi, and M. Luisi, Effects of fenfluramine and ritanserin on prolactin response to insulin-induced hypoglycemia in obese patients: evidence for failure of the serotoninergic system, Horm Res 31: 133–137, 1989.

    Article  PubMed  CAS  Google Scholar 

  33. Giaufre, E., B. Conte-Devolx, G. Morisson-Lacombe, F. Boudouresque, M. Grino, B. Rousset-Rouviere, V. Guillaume, and C. Oliver, Anesthesie peridurale par voie caudal chez l’enfant. Etude des variations endocriniennes, La Presse Médicale 14: 201–203, 1985.

    PubMed  CAS  Google Scholar 

  34. Imura, H., Y. Nakai, and T. Yoshimi, Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man, J Clin Endocrinol Metab 36: 204–206, 1973.

    Article  PubMed  CAS  Google Scholar 

  35. Modlinger, R.S, J.M. Schonmuller, and S.P. Arora, Adrenocorticotropin release by tryptophan in man, J Clin Endocrinol Metab 50: 360–363, 1980.

    Article  PubMed  CAS  Google Scholar 

  36. Woolf, P.D., and L. Lee, Effects of the serotonin precursor, tryptophan, on pituitary hormone secretion, J Clin Endocrinol Metab 45: 123–133, 1977.

    Article  PubMed  CAS  Google Scholar 

  37. Lewis, D.A., and B.M. Sherman, Serotonergic stimulation of adrenocorticotropin secretion in man, J Clin Endocrinol Metab 58: 458–462, 1984.

    Article  PubMed  CAS  Google Scholar 

  38. Vague, J., P.H. Vague, J. Boyer, and M.C. Cloix, Antropometry of obesity. Diabetes, adrenal and beta-cell functions, In R.R. Rodriguez and J. Vallance-Owen (eds) Diabetes ,Excerpta Medica, Amsterdam, pp. 517–525, 1971.

    Google Scholar 

  39. Mashchak, CA., O.A. Kletzky, C. Spencer, and R. Artal, Transient effect of L-5-hydroxytryptophan on pituitary function in men and women, J Clin Endocrinol Metab 56: 170–176, 1983.

    Article  PubMed  CAS  Google Scholar 

  40. Masala, A., G. Delitala, and L. Devilla, Enhancement of insulin-induced prolactin secretion by fluoxetine in man, J Clin Endocrinol Metab 49: 350–352, 1979.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. D. Ježová

    Present address: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlárska 3, 83306, Bratislave, Czechoslovakia

Authors and Affiliations

  1. Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, Bd P. Dramard, 13326, Marseille Cédex 15, France

    C. Oliver, D. Ježová, M. Grino, V. Guillaume, F. Boudouresque, B. Conte-Devolx, G. Pesce, A. Dutour & D. Becquet

Authors
  1. C. Oliver
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Ježová
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Grino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. Guillaume
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Boudouresque
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. Conte-Devolx
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. Pesce
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. Dutour
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. D. Becquet
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    John C. Porter

  2. Institute of Experimental Endocrinology, Bratislava, Czechoslovakia

    Daniela Ježová

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Oliver, C. et al. (1990). Differences in the Effects of Acute and Chronic Administration of Dexfenfluramine on Cortisol and Prolactin Secretion. In: Porter, J.C., Ježová, D. (eds) Circulating Regulatory Factors and Neuroendocrine Function. Advances in Experimental Medicine and Biology, vol 274. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5799-5_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5799-5_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5801-5

  • Online ISBN: 978-1-4684-5799-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation