Host-Parasite Interaction-Mechanisms of Pathogenesis

Abstract

The asymptomatic presence on mucous membranes of Candida cells, especially of Candida albicans, is widespread in healthy,persons. A sensible disturbance of such host-parasite relationship has to occur to make this opportunist a microbial aggressor. While transitory superficial infections by Candida species represent the bulk of such disorders, serious clinical forms as well as generalized visceral invasion with sometimes fatal outcome may result. The bulk of clinical observations indicates that changes on the side of the affected carrier are primarily responsible in destabilizing this equilibrium: such as disturbances of cellular defence mechanisms and the immune system, the alteration of the normal microbial flora and the hormonal state. These factors seem to be primarily involved in the steadily increasing frequency of Candida infections. The growing incidence and the therapeutic constraints in severe Candida invasion represent an alarming problem in medical care. In order to develop prophylactic strategies, a profound understanding of the molecular events that accompany these disorders will be necessary.