Abstract
Delta-9-tetrahydrocannabinol (THC) is a small molecular weight lipophilic substance which is the primary psychoactive ingredient present in marijuana. This three-ringed molecule has been shown to bind to serum lipoproteins and is believed to exert much of its psychoactive effects by its ability to bind to membranes of cells in the central nervous system (1). The mechanism by which THC exerts psychoactive activity is unknown.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
B. R. Martin, Cellular effects of cannabinoids, Pharmacol. Rev. 38:45 (1986).
B. E. Juel-Jensen, Brit. Med. J. iv: 296 (1972).
P. S. Morahan, P. C. Klykken, S. H. Smith, L. S. Harris, and A. E. Munson, Effects of cannabinoids on host resistance to Listeria monocytogenes and herpes simplex virus, Infect. Immun. 23:670 (1979).
R. D. Blevins and M. P. Dumic, The effect of 9-tetrahydrocannabinol on herpes simplex virus replication, J.gen. Virol. 49:427 (1980).
G. A. Cabral, P. J. McNerney, and E. M. Mishkin, tetrahydrocannabinol enhances release of herpes simplex virus type 2, J. gen. Virol. 67:2017 (1986).
G. A. Cabral, P. J. McNerney, and E. M. Mishkin, Effect of micromolar concentrations of delta-9-tetrahydrocannabinol on herpes simplex virus type 2 replication in vitro, J. Toxicol. Envir. Health. 21:277 (1987).
R. D. Blevins and J. D. Regan, Delta-9-tetrahydrocannabinol: Effect on macromolecular synthesis in human and other mammalian cells, ArchToxicol. 35:127 (1976).
M. J. Mon, R. L. Jansing, S. Doggett, J. L. Stein, and G. S. Stein, Influence of delta-9-tetrahydrocannabinol on cell proliferation and macromolecular biosynthesis in human cells, Biochem. Pharmacol. 27:1759 (1978).
M. J. Mon, A. E. Haas, J. L. Stein and G. S. Stein, Influence of psychoactive and nonpsychoactive cannabinoids on cell proliferation and macromolecular biosynthesis in human cells, Biochem. Pharmacol. 30:31 (1981).
S. L. Palmer, Effects of 9-tetrahydrocannabinol on growth, morphological characteristics, macromolecular synthesis and nucleotide pools of HeLa-S3 cells, Ph.D. Dissertation, University of Toronto (1981).
G. J. Lancz, Herpes simplex viruses types 1 and 2: Type and strain specific characteristics affecting virus plaque formation, Archiv. ges. Virusforsch.46:36 (1974).
G. J. Lancz, and J. J. Bradstreet, pH-mediated inhibition of the cell to cell spread of herpes simplex virus infection, Arch. Virol. 52:37 (1976).
R. Laskov, G. Lancz, N. H. Ruddle, K. M. McGrath, S. Specter, T. Klein, J. Djeu, and H. Friedman, Production of tumor necrosis factor (TNF alpha) and lymphotoxin (TNF beta) by murine pre-B and B cell lymphomas, J. Immunol. (in press, 1990).
R. J. Ash, Butyrate-induced reversal of herpes simplex virus restriction in neuroblastoma cells, Virology. 155:584 (1986).
G. J. Lancz, Physical integrity of herpes simplex virus following thermal inactivation, Arch. Virol. 64:3755 (1980).
G. J. Lancz, B. A. Hulick, R. J. Grasso, and L. Skinner, Glucocorticoid mediated establishment of an antiviral state coincident with other gluco-corticoid-induced biochemical activities in L929 cells, J. gen. Virol. 66:2249 (1985).
G. J. Lancz, Effect of pH on the kinetics of herpes simplex virus inactivation at 36°C, Virology. 75:488 (1976).
G. Lancz, and J. Sample, Thermal-pH inactivation of herpes simplex virus: Interdependence of the medium composition and the pH of the rate of virus inactivation, Arch. Virol. 84:141 (1985).
M. Sarmiento, M. Haffey, and P. G. Spear, Membrane proteins specified by herpes simplex viruses. III Role of glycoprotein VP 7 (B 2) in virion infectivity, J. Virol. 29:1149 (1979).
M. W. Ligas, and D. C. Johnson, A herpes simplex virus mutant in which glycoprotein D sequences are replaced by ß-galactosidase sequences binds to but is unable to penetrate into cells, J. Virol. 62:1486 (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Lancz, G., Specter, S., Brown, H.K., Hackney, J.F., Friedman, H. (1991). Interaction of Delta-9-Tetrahydrocannabinol with Herpesviruses and Cultural Conditions Associated with Drug-Induced Anti-Cellular Effects. In: Friedman, H., Specter, S., Klein, T.W. (eds) Drugs of Abuse, Immunity, and Immunodeficiency. Advances in Experimental Medicine and Biology, vol 288. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5925-8_33
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5925-8_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5927-2
Online ISBN: 978-1-4684-5925-8
eBook Packages: Springer Book Archive