Abstract
Head and neck cancer is a devastating malignancy that afflicts approximately 53,500 Americans annually (1). This disease generally begins in the mucosal lining of the upper aerodigestive tract and is most commonly seen in the larynx, oral cavity, and oral and hypopharynx. It is a relatively slow growing tumor that remains localized for varying lengths of time and then metastasizes to regional lymphatics. Distant spread outside the head and neck is uncommon in the early cases; and it is not uncommon to find patients with lesions existing one year or longer, and attaining considerable size without metastasis below the clavicles. The majority of these tumors are squamous cell carcinomas by histology. Early tumors can be successfully treated by conservative surgery or irradiation therapy. Advanced cancers necessitate wide-field resection often with the addition of postoperative radiation therapy. Although this aggressive approach produces acceptable therapeutic results, it leaves many patients with impaired physiologic functioning and a disordered appearance.
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References
E. Silverberg, Cancer Statistics 1984, Cancer 34:9 (1984).
Marijuana and the lungs. A position paper by the American Thoracic Society: American Thoracic Society News, p. 7, Spring (1975).
P. J. Donald, R. H. Hages, and R. Dhaliwal, Combined treatment for pyriform sinus carcinoma using postoperative irradiation, Otolaryngol. Head Neck Surg. 88:738 (1980).
K. O. Fehr and H. Kalant, Analysis of cannabis smoke obtained under different combustion conditions, Can. J. Physiol. Pharmacol. 50:761 (1972).
K. O. Fehr and H. Kalant, Cannabis health hazards: Proceedings of an ARF/ WHL Scientific Meeting on Adverse Health and Behavioral Consequences of Cannabis Use, Addiction Research Foundation, p. 501, Toronto (1983).
C. Leuchtenberger, R. Leuchtenberger, and A. Schneider, Effects of marijuana and tobacco smoke on human lung physiology, Nature 241: 137 (1973).
C. Leuchtenberger, R. Leuchtenberger, and U. Ritter, Effects of marijuana and tobacco smoke on D.N.A. and chromosomal compliment in human lung explants, Nature 242:404, (1973).
S. S. Mitsuyama, L. F. Jarvik, T. K. Fu, and F. S. Yen, Chromosome studies before and after supervised marijuana smoking, in: “Pharmacology of Marijuana,” Vol. 2, M. C. Braude and S. Szara, eds., Raven Press, New York, (1976).
B. H. Petersen, L. Lemberger, J. Graham, and B. Dalton, Alterations in the cellular-mediated immune responsiveness of chronic marijuana smokers, Psychopharmacol. Commun. 1:67 (1975).
G. G. Nahas, B. Desoize, J. P. Armand, J. Hsu, and A. Morishima, Natural cannabinoids: Apparent depression of nucleic acids and protein synthesis and cultures of human lymphocytes, in: “Pharmacology of Marijuana,” S. Szara and M. Braude, eds., Raven Press, New York (1975).
G. G. Nahas, Psychoactive drugs and immune response, Presented at Drugs of Abuse, Immunity, and Immunodeficiency, Clearwater FL, December 13–15 (1989).
A. M. Zimmerman, N. Titischov, S. Zimmerman, and R. Mechoulam, Enantiomeric cannabinoid effects on the immune system of mice, Presented at Drugs of Abuse, Immunity, and Immunodeficiency, Clearwater, FL, December 13–15 (1989).
P. Cushman and R. Khurana, Marijuana and T-lymphocyte rosettes, Clin. Pharmacol. Ther. 19:310 (1976).
P. Cushman, M. Grieco, and S. Gupta, Reduction in T-lymphocytes forming active rosettes in chronic marijuana smokers, Int. J. Clin. Pharmacol. Bio-pharm. 12:217 (1975).
R. Hong and S. Horowitz, Thymosin therapy creates a “Hassal?” N. Eng. J. Med. 292:104 (1975).
S. Specter, Effects of marijuana on natural killer cell activity in man, Presented at Drugs of Abuse, Immunity, and Immunodeficiency, Clearwater, FL, December 13–15 (1989).
B. Waltz, P. Scuderi, and R. R. Watson, Influence of marijuana components (THC and CBD) on human mononuclear cells cytokine secretion in vitro ,Presented at Drugs of Abuse, Immunity, and Immunodeficiency, Clearwater, FL, December 13–15 (1989).
G. S. Rachelefsky and G. Opelz, Normal lymphocyte function in the presence of A9-THC, CHn. Pharmacol. Ther. 21:44 (1977).
S. C. White, S. C. Brin, and B. W. Janicki, Mitogen-induced blastogenic responses of lymphocytes from marijuana smokers, Science 88:71 (1975).
P. E. Roy, F. Manan-Lapoint, N. D. Huy, et al., Chronic inhalation of marijuana and tobacco in dogs: Pulmonary pathology, Res. Commun. Chem. Pathol. Pharmacol. 14:305 (1976).
H. Rosenkrantz and R. W. Fleischman, Effects of cannabis on lungs, in: “Advances in the biosciences,” Vols. 22 and 23, p. 279, G. G. Nahas and W. D. M. Paton, eds., Pergamon Press, New York (1979).
R. D. Magus and L. S. Harris, Carcinogenic potential of marijuana smoke condensate, Fed. Proc. (Abstract) 30:179 (1971).
D. Hoffman, K. D. Brunnemann, G. B. Gori, and E. L. Wynder, On the carcinogenicity of marijuana smoke, Recent Adv. Phytochem. 9:63 (1975).
J. L. Montour, W. Dutz, and L. S. Harris, Modification of radiation carcinogenesis by marijuana, Cancer 47:1279 (1981).
R. L. Henderson, F. S. Tennant, and R. Guerry, Respiratory manifestations of hashish smoking, Arch. Otolaryngol. 95:248 (1972).
P. G. Colon, Oral papilloma in marijuana users, Quintessence International -Report #1839, p. 75 (1980).
J. Endicott, Personal communication (1989).
J. Palmer, Personal communication (1985).
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Donald, P.J. (1991). Advanced Malignancy in the Young Marijuana Smoker. In: Friedman, H., Specter, S., Klein, T.W. (eds) Drugs of Abuse, Immunity, and Immunodeficiency. Advances in Experimental Medicine and Biology, vol 288. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5925-8_4
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DOI: https://doi.org/10.1007/978-1-4684-5925-8_4
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