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Animal Models of Generalized Convulsive Seizures: Some Neuroanatomical Differentiation of Seizure Types

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Generalized Epilepsy

Abstract

Despite our ability to characterize, classify, and treat numerous forms of epileptic seizures, our understanding of the neuroanatomical and neurochemical substrates of seizures is remarkably limited. Even in animal models, in which we often have experimental control over seizure onset, intensity, duration, and quality, we are at a loss to define the precise neural pathways that are responsible for the various stages of seizure development. Clearly, an understanding of this nature would be of major benefit in providing insights regarding both potential substrates of pathology as well as therapeutic interventions for seizure disorders.

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Authors
  1. K. Gale
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Editors and Affiliations

  1. Montreal Neurological Institute, Department of Neurophysiology, McGill University, H3A 2B4, Montreal, Quebec, Canada

    Massimo Avoli M.D., Ph.D.  & Pierre Gloor Ph.D.  & 

  2. Department of Physiology, University of Patras Medical School, 261 10, Patras, Greece

    George Kostopoulos M.D., Ph.D.

  3. Laboratoire de Physiologie Nerveuse, CNRS, F-91198, Gif-sur-Yvette, France

    Robert Naquet M.D.

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Gale, K. (1990). Animal Models of Generalized Convulsive Seizures: Some Neuroanatomical Differentiation of Seizure Types. In: Avoli, M., Gloor, P., Kostopoulos, G., Naquet, R. (eds) Generalized Epilepsy. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6767-3_23

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  • DOI: https://doi.org/10.1007/978-1-4684-6767-3_23

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6769-7

  • Online ISBN: 978-1-4684-6767-3

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