Abstract
Chronic exposure to an excess of adrenal androgens has been linked to the pathophysiology and the clinical picture of such endocrinological disorders as polycystic ovary syndrome (1), congenital adrenal hyperplasia (2), and hirsutism (3), conditions often associated with impaired fertility. The purpose of our study was to investigate subacute effects of elevated adrenal androgen levels on gonadotropin secretion and sex steroid concentrations in female monkeys. Of all adrenal androgens, dehydroepiandrosterone sulfate (DS) is the most abundant in the circulation, has the lowest metabolic clearance rate, and can be converted in vivo to other adrenal androgens (4). For these reasons, this steroid was chosen as a model for studying the influence of adrenal hyperandrogenaemia on the hormones of the pituitary-ovarian axis.
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References
DeVane GW, Czekala NM, Judd HL, Yen SSC. Circulating gonadotropins, estrogens, and androgens in polycystic ovarian disease. Am J Obstet Gynecol 1975; 121: 496–500.
Cassorla FG, Chrousos GP. Congenital adrenal hyperplasia. In: Becker KL, ed. Principles and practice of endocrinology and metabolism. Philadelphia: JB Lippincott 1990: 604–13.
Parker LN. Hirsutism. In: Parker LN. Adrenal androgens in clinical medicine. New York: Academic Press, 1989: 298–319.
Parker LN. Adrenal androgen metabolism. In: Parker LN. Adrenal androgens in clinical medicine. New York: Academic Press, 1989: 3–29.
Keller-Wood ME, Dallman MF. Corticosteroid inhibition of ACTH secretion. Endocr Rev 1984; 5: 1–24.
Nakai Y, Plant TM, Hess DL, Keogh ET, Knobil E. On the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion in the rhesus monkey. Endocrinology 1978; 102: 1008–14.
Maruyama Y, Aoki N, Suzuki Y, et al. Sex-steroid binding protein (SBP), testosterone oestradiol and DHEA in prepuberty and puberty. Acta Endocrinol 1987; 114: 60–7.
Dubey AK, Plant TM. Testosterone administration to ovariectomized monkeys (Macaca mulatta) reduces the frequency of pulsatile luteinizing hormone secretion. Biol Reprod 1985; 32: 1109–15.
McLachlan RI, Cohen NL, Vale WW, et al. The importance of luteinizing hormone in the control of inhibin and progesterone secretion by the human corpus luteum. J Clin Endocrinol Metab 1989; 68: 1078–85.
Lenton EA, Sexton L, Lee S, Cook ID. Progressive changes in LH and FSH and LH: FSH ratio in women throughout reproductive life. Maturitas 1988; 10: 35–43.
Geola FL, Frumar AM, Tataryn IV, et al. Biological effects of various doses of conjugated equine estrogens in postmenopausal women. J Clin Endocrinol Metab 1980; 51: 620–5.
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© 1992 Springer-Verlag New York, Inc.
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Kowalski, W., Chatterton, R.T. (1992). Modulation of Gonadotropin and Sex Steroid Levels by Adrenal Androgens with Osmotic Pumps. In: Hunzicker-Dunn, M., Schwartz, N.B. (eds) Follicle Stimulating Hormone. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7103-8_37
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DOI: https://doi.org/10.1007/978-1-4684-7103-8_37
Publisher Name: Springer, New York, NY
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