Abstract
Glyoxylic acid (GA) is the major precursor of endogenous oxalate and is mainly derived from glycine, glycolate and hydroxyproline. It can be either converted to C02 in liver and kidney mitochondria by TPP-dependent α-ketoglutarate:GA carboligase1 and via the glyoxylate oxidation cycle2, or it can be oxidized to oxalate by glycolic acid oxidase (GAO) and lactate dehydrogenase (LDH). Thiamine deficiency leads to excessive accumulation of GA in tissues and its increased excretion in urine3,4 and may result in a greater incidence of renal calculi5,6. There are, however, contradictory reports on the effect of thiamine deficiency on oxalate excretion7,8. The present study tries to elucidate the biochemical cause of the hyperoxaluria in thiamine deficiency.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M. A. Schlossberg, R. J. Bloom, D. A. Richert, and W. W. Westerfield, Biochem. 9:1148 (1970).
E. E. Dekker and S. C. Gupta, Fed. Proc. 38:2339 (1979).
C. C. Liang, Biochem. J. 82:429 (1962).
R. M. Buckle, Clin. Sci. 25:207 (1963).
S. Davidson, A. P. Meiklejohn, and R. Passmore, “Human Nutrition and Dietetics”, Williams & Wilkins, Baltimore (1959).
S. Dhanmitta, A. Valyasevi, and R. Van Reen, Nutr. Rep. Int. 2:87 (1970).
E. Takasaki, Invest. Urol. 7:150 (1969).
S. Hauschildt, R. Rudolph, and W. Feldheim, Int. J. Vitaminol. Nutr. Res. 42:457 (1972).
L. Boni, L. Kieckens, and A. Hendrikx, J. Nutr. Sci. Vitaminol. 26:507 (1980).
H. Kishi and K. Folkares, J. Nutr. Sci. Vitaminol. 22:225 (1976).
J. V. O’Fallon and R. W. Brosemer, Biochim. Biophys. Acta 499:321 (1977).
V. Sharma, M. S. R. Murthy, S. K. Thind, and R. Nath, Biochem. Int. 3:507 (1981).
A. Hodgkinson and A. Williams, Clin. Chim. Acta 36:127 (1972).
J. C. D. White and D. T. Davies, J. Dairy Res. 30:171 (1963).
R. G. Rosso and E. Adams, J. Biol. Chem. 23:5524 (1967).
A. Ruffo, E. Testa, A. Adinolfi, G. Pelizza, and R. Moratti, Biochem. J. 103:19 (1967).
C. J. Gubler, J. Biol. Chem. 236:312 (1961).
A. Weinhouse, in: “Symposium on Amino Acid Metabolism”, W. D. McElroy and H. B. Glass, eds., John Hopkins Press, Baltimore (1955).
A. Ruffo, A. Adinolfi, G. Budillon, and G. Capobianco, Biochem. J. 85:593 (1962).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this paper
Cite this paper
Thind, S.K., Sidhu, H., Nath, R. (1985). Glyoxylate Oxidation and Enzymes of Oxalate Biosynthesis in Thiamine-Deficient Rats. In: Schwille, P.O., Smith, L.H., Robertson, W.G., Vahlensieck, W. (eds) Urolithiasis and Related Clinical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7272-1_45
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7272-1_45
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7274-5
Online ISBN: 978-1-4684-7272-1
eBook Packages: Springer Book Archive