Abstract
Emulsions of perfluorochemicals (PFC) in isotonic electrolyte solutions are known to have properties which make them attractive as physiological oxygen-transport fluids. Such properties include: the ability to dissolve substantial volumes of oxygen and other respiratory gases; and their small particle sizes (< 0.25 µm) which enable them to pass through capillary beds. In addition, due to the strength of the carbon-fluorine bond (ca. 116 kcal/mol), the PFC themselves are generally regarded as being both chemically and biologically inert (Riess and Le Blanc, 1982). Some of the physiological effects of emulsified PFC have been studied in several species and also in experiments using mammalian cells in culture (Lowe and Bollands, 1985; Lowe, 1986).
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Sharma, S.K., Bollands, A.D., Davis, S.S., Lowe, K.C. (1987). Emulsified Perfluorochemicals as Physiological Oxygen-Transport Fluids: Assessment of a Novel Formulation. In: Silver, I.A., Silver, A. (eds) Oxygen Transport to Tissue IX. Advances in Experimental Medicine and Biology, vol 215. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7433-6_12
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DOI: https://doi.org/10.1007/978-1-4684-7433-6_12
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