Abstract
Kininogen disappears from peripheral blood after hepatectomy or intoxication with carbon tetrachloride (1), a point that suggests that kininogen is synthesized by the liver. In the present study we have tested this possibility by perfusing the isolated liver with Krebs-Henseleit solution containing 14C-arginine and 14C-proline. The radioactive protein formed by the isolated liver reacts with a specific kininogenase (2) to produce a radioactive peptide indistinguishable from bradykinin. We interpret our data to mean that kininogen is synthesized by the liver.
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This research was supported in part by grants from the Florida Heart Association and the U.S. Public Health Service (HE 12843 and HE 14360.
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© 1972 Plenum Press, New York
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Bryan, F.T., Ryan, J.W., Niemeyer, R.S. (1972). Bradykininogen Synthesis by Liver. In: Back, N., Sicuteri, F. (eds) Vasopeptides. Advances in Experimental Medicine and Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7439-8_5
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DOI: https://doi.org/10.1007/978-1-4684-7439-8_5
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