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Integral Membrane Glycoproteins in Cell-Cell and Cell-Substratum Adhesion

  • Chapter
The Biology of Glycoproteins

Abstract

The focus of this chapter is on the integral membrane glycoproteins of the animal cell involved in cell-cell and cell-substratum adhesion. The approach to the subject, both intellectually and experimentally, reflects not only the prejudices of the authors but also the ideas and concepts gleaned from the literature and from conversations with colleagues. For the free interchange of ideas, we are grateful; for misinterpretations or oversights, we apologize. We have focused attention on that body of experimental data that has used both biochemical and biological approaches in an attempt to understand the adhesion process. Immunology, with its potential for specificity, has played a particularly crucial role in the discovery of adhesion-related glycoproteins and, with the increased use of monoclonal antibody technology, will play an increasingly important role in exploring this area. It is a tool that must be used with caution, however, as will be noted throughout the chapter.

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  1. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, 19104, USA

    Caroline H. Damsky, Karen A. Knudsen & Clayton A. Buck

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  1. Caroline H. Damsky
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  2. Karen A. Knudsen
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  1. M. D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, Texas, USA

    Raymond J. Ivatt

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Damsky, C.H., Knudsen, K.A., Buck, C.A. (1984). Integral Membrane Glycoproteins in Cell-Cell and Cell-Substratum Adhesion. In: Ivatt, R.J. (eds) The Biology of Glycoproteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7464-0_1

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