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Formation of Aberrant Neurotransmitters and Its Implication for Alcohol Addiction and Intoxication

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Biochemical Pharmacology of Ethanol

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 56))

Abstract

The non- specific amine substitution in nerve- endings has been most clearly expressed in the concept of “false adrenergic transmitters” (1,2). This concept has been explored in detail by Kopin (3,4). The major criteria to identify false transmitters (3) are similar to those for transmitters per se (5).

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References

  1. Carlsson, A. and Lindqvist, M.: In vivo decarboxylation of alpha-methyl-dopa and alpha-methyl tyrosine. Acta Physiol. Scand., 54: 87–94, 1962.

    Article  PubMed  CAS  Google Scholar 

  2. Day, M.D. and Rand, M.J.: Awakening from reserpine sedation by alpha-methyl-dopa. J. Pharm. Pharmacol., 15: 631–632, 1963.

    Article  PubMed  CAS  Google Scholar 

  3. Kopin, I.J.: False adrenergic transmitters. Ann. Rev. Pharmacol., 10: 377–394, 1968.

    Article  Google Scholar 

  4. Kopin, I.J.: Unnatural amino acids as precursors of false transmitters. Fed. Proc., 30: 904–907, 1971.

    PubMed  CAS  Google Scholar 

  5. Alivisatos, S.G.A. and Seth, P.K.: Current approaches in the study of receptors in the CNS. In: Methods in Neurochemistry, R. Fried, (ed.), Marcel Dekker, Inc, 2: 205–273, 1971.

    Google Scholar 

  6. Muscholl, E. and Maitre, L.: Release by sympathetic stimulation of a-methyl noradrenaline stored in heart after administration of a-methyldopa. Experientia, 19: 658–659, 1963.

    Article  PubMed  CAS  Google Scholar 

  7. Cohen, G.: Tetrahydroisoquinoline alkaloids, uptake, storage and secretion by the adrenal medulla and by adrenergic nerves. In: Alcoholism and the Central Nervous System. F.A. Seixas and Suzie Eggleston, (eds.), Ann. N.Y. Acad. Sci., 215: 116119, 1973.

    Google Scholar 

  8. Mclsaac, W.M.: Formation of 1-methyl-6-methoxy 1,2,3,4-tetrahydro-2-carboline under physiological conditions. Biochim. Biophys. Acta, 52: 607–609, 1961.

    Article  Google Scholar 

  9. Dajani, R.M. and Saheb, S.E.: A further insight into the metabolism of certain ß-carbolines. In: Alcoholism and the Central Nervous System. Frank A. Seixas and Suzie Eggleston, (eds.), Ann. N.Y. Acad. Sci., 215: 120–123, 1973.

    Google Scholar 

  10. Murphy, D.L.: Amine precursors, amines and false neurotransmitters in depressed patients. Amer. J. Psychiat., 129: 141–148, 1972.

    PubMed  CAS  Google Scholar 

  11. Davis, V.E. and Walsh, M.J.: Alcohol, amines and alkaloids: A possible biochemical basis for alcohol addiction. Science, 167: 1005–1007, 1970.

    Article  PubMed  CAS  Google Scholar 

  12. Davis, V.E.: Neuroamine-derived alkaloids: A possible common denominator in alcoholism and related drug dependencies. In: Alcoholism and the Central Nervous System. Frank A. Seixas and Suzie Eggleston, (eds.), Ann. N.Y. Acad. Sci., 215: 111115, 1973.

    Google Scholar 

  13. Cohen, G. and Collins, M.: Alkaloids from catecholamines in adrenal tissue: Possible role in alcoholism. Science, 167: 1749–1751, 1970.

    Article  PubMed  CAS  Google Scholar 

  14. Alivisatos, S.G.A., Ungar, F., Callaghan, 0.H., L.vitt, L.P. and Tabakoff, B.: Inhibition of the formation of tetrahydroisoquinoline alkaloids in brain homogenates. Canad. J. Biochem., 51: 28–38, 1973.

    Google Scholar 

  15. Walsh, M.J.: Biogenesis of biologically active alkaloids from amines by alcohol and acetaldehyde. In: Alcoholism and the Central Nervous System. Frank A. Seixas and Suzie Eggleston, (eds.), Ann. N.Y. Acad. Sci., 215: 98–110, 1973.

    Google Scholar 

  16. Leete, E.: The biogenesis of morphine. J. Amer. Chem. Soc., 81: 3948–3951, 1959.

    Article  CAS  Google Scholar 

  17. Battersby, A.R.: Alkaloid biosynthesis. Quart. Rev., 15: 259286, 1961.

    Google Scholar 

  18. Kirby, G.W.: Biosynthesis of the morphine alkaloids. Science, 155: 170–173, 1967.

    Article  PubMed  CAS  Google Scholar 

  19. Collins, M.A.: Tetrahydroisoquinoline alkaloids from condensation of alcohol metabolites with norepinephrine: preparative synthesis and potential analysis in nervous tissue by Gas-Chromatography. In: Alcoholism and the Central Nervous System. Frank A. Seixas and Suzie Eggleston, (eds.), Ann. N.Y. Acad. Sci., 215: 92–97, 1973.

    Google Scholar 

  20. Alivisatos, S.G.A., Callaghan, 0.H., Ungar, F., Georgiou, D.C. and Tabakoff, B.: Inhibition of tetrahydroisoquinoline alkaloid formation in brain homogenates by ascorbate (A), cysteine (C) and GSH, and its significance in alcohol addiction. Amer. Chem. Soc. Div. Biol. Chem., Abs., 211: 1971.

    Google Scholar 

  21. French, D. and Edsall, J.T.: The reactions of formaldehyde with amino acids and proteins. Adv. Protein Chem., 2: 277–335, 1945.

    Article  CAS  Google Scholar 

  22. Sandler, M., Carter, S.B., Hunter, K.R. and Stern, G.M.: Tetrahydroisoquinoline alkaloids: In vivo metabolites of L-Dopa in man. Nature, 241: 439–443, 1973.

    Article  PubMed  CAS  Google Scholar 

  23. Majchrowicz, E. and Mendelson, J.H.: Blood methanol concentrations during experimentally induced ethanol intoxication in alcoholics. J. Pharmacol. Exp. Ther., 179: 293–300, 1971.

    PubMed  CAS  Google Scholar 

  24. Alivisatos, S.G.A. and Ungar, F.: Incorporation of radioactivity from labeled serotonin and tryptamine into acid-insoluble material from subcellular fractions of brain. 1. The nature of the substrate. Biochemistry, 7: 285–292, 1968.

    Article  PubMed  CAS  Google Scholar 

  25. DeRobertis, E., Alberici, M., Arnaiz, G.R. deLores and Azcurra, J.M.: Isolation of different types of synaptic membranes from the brain cortex. Life Sci, 5: 577–582, 1966.

    Article  CAS  Google Scholar 

  26. Ungar, F., Tabakoff, B. and Alivisatos, S.G.A.: Inhibition of binding of aldehydes of biogenic amines in tissue. Biochem. Pharmacol., 22: 1905–1913, 1973.

    Article  PubMed  CAS  Google Scholar 

  27. Erwin, V.G., Tabakoff, B. and Bronaugh, R.L.: Inhibition of reduced NADP-linked aldehyde reductase from bovine brain by barbiturates. Molec. Pharmacol., 7: 169–176, 1971.

    CAS  Google Scholar 

  28. Tabakoff, B., Ungar, F. and Alivisatos, S.G.A.: Aldehyde derivatives of indoleamines: Enhancement of their binding onto brain macromolecules by pentobarbital and acetaldehyde. Nature, 238: 126–128, 1973.

    Google Scholar 

  29. Tanzer, M.L.: Cross-linking of collagen. Science, 180: 56 1566, 1973.

    Google Scholar 

  30. Alivisatos, S.G.A., Ungar, F., Seth, P.K., Levitt, L.P., Geroulis, A.J. and Meyer, T.S.: Receptors: Localization and specificity of binding of serotonin in the central nervous system. Science, 171: 809–812, 1971.

    Article  PubMed  CAS  Google Scholar 

  31. Symes, A.L. and Sourkes, T.: Pharmacological and biochemical actions of the hemolytic agents acetylphenylhydroxin and phenylhydraxine on MAO in the rat brain. Biochem. Pharmacol., 23: 2045–2056, 1974.

    Article  PubMed  CAS  Google Scholar 

  32. Victor, M.: Treatment of alcoholic intoxication and the withdrawal syndrome. Psychocoat. Med., 28: 436–450, 1966.

    Google Scholar 

  33. Majchrowicz, E.: Ethanol induced accumulation of methanol in alcoholic subjects. Am. Chem. Soc. Div. Biol. Chem., p. 144, Abs., 1973.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, The Chicago Medical School, University of Health Sciences, Chicago, Ill., USA

    Spyridon G. A. Alivisatos & Ramesh C. Arora

Authors
  1. Spyridon G. A. Alivisatos
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  2. Ramesh C. Arora
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Editor information

Editors and Affiliations

  1. Laboratory of Alcohol Research, National Institute on Alcohol Abuse and Alcoholism, Washington, D.C., USA

    Edward Majchrowicz

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© 1975 Plenum Press, New York

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Alivisatos, S.G.A., Arora, R.C. (1975). Formation of Aberrant Neurotransmitters and Its Implication for Alcohol Addiction and Intoxication. In: Majchrowicz, E. (eds) Biochemical Pharmacology of Ethanol. Advances in Experimental Medicine and Biology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7529-6_12

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  • DOI: https://doi.org/10.1007/978-1-4684-7529-6_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7531-9

  • Online ISBN: 978-1-4684-7529-6

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