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The Effect of Opsonized Colloids on the Enhancement of Endotoxin Lethality

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The Reticuloendothelial System and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1))

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Abstract

The diverse physiologic functions which are altered following the intravenous injection of inert particles, have imposed, a priori, on the reticuloendothelial system (RES) a significance which belies its morphological appearance. This is exemplified by the striking increase in the sensitivity of several species of animals to the lethal effects of endotoxin when given within a definite interval of time after the intravenous injection of colloidal material [1]. Since the majority of these colloidal particles are phagocytized by the fixed reticuloendothelial cells of the liver and spleen, it has been suggested [2] that the functions of the RE cells are impaired for a variable period of time due to the presence of a mass of inert material contained within their cytoplasm. Blockaded RE cells would be temporarily unable to phagocytose additional foreign material such as endotoxins.

This study was supported by research grant AI-05913 from the National Institute of Allergy and Infectious Diseases, U. S. Public Health Service.

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Author information

Authors and Affiliations

  1. Department of Anatomy, State University of New York Downstate Medical Center, Brooklyn, New York, USA

    I. MacKay Murray

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  1. I. MacKay Murray
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Editors and Affiliations

  1. Department of Physiology and Biophysics, University of Tennessee Medical Units, Memphis, Tennessee, USA

    Nicholas R. Di Luzio (President) (President)

  2. Institute of Pharmacology, University of Milan, Milan, Italy

    Rodolfo Paoletti

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© 1967 Springer Science+Business Media New York

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Murray, I.M. (1967). The Effect of Opsonized Colloids on the Enhancement of Endotoxin Lethality. In: Luzio, N.R.D., Paoletti, R. (eds) The Reticuloendothelial System and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7796-2_26

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  • DOI: https://doi.org/10.1007/978-1-4684-7796-2_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7798-6

  • Online ISBN: 978-1-4684-7796-2

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