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Correlation Between K+ Fluxes and the Arachidonic Acid Cascade in Human Leukocyte Stimulated with a 23187 or Melittin

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Drugs Affecting Leukotrienes and Other Eicosanoid Pathways

Part of the book series: NATO ASI Series ((NSSA,volume 95))

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Abstract

It is well known that leukocytes play key roles in mechanisms of body defense against both endotoxins and exotoxins. The factors involved in triggering such defense mechanisms involve an activation of cellular membrane processes, among which is the release (from phospholipids) of AA and its subsequent metabolism into various icosanoids. The liberation of such icosanoids (e.g. LTs, PGs, HPETEs), in addition to the formation of superoxide and other oxygen free radicals and the liberation of histamine and certain degradative enzymes (e.g., elastase, collagenase), play key roles not only in the destruction of suitable ingestible particles but also in the recruitment (chemotaxic effect) of other cells for this process. All of these events depend upon the generation and transmission of a membrane signal which involves mainly membrane metabolism and ion transport1.

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Author information

Authors and Affiliations

  1. C.R.S.S.A., Division de Radiobiochimie, lbis rue Raoul Batany, F-92141, Clamart, France

    Monique Braquet

  2. INSERM U7, Hopital Necker, 171 rue de Sèvres, F-75015, Paris, France

    Mara d’Onofrio & Ricardo Garay

  3. I.H.B. Research Laboritories, 17 avenue Descates, F-92350, Le Plessis, France

    Pierre Braquet

Authors
  1. Monique Braquet
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  2. Mara d’Onofrio
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  3. Ricardo Garay
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  4. Pierre Braquet
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Editor information

Editors and Affiliations

  1. Karolinska Institute, Stockholm, Sweden

    B. Samuelsson

  2. University of Milan, Milan, Italy

    F. Berti  & G. C. Folco  & 

  3. University of Verona, Verona, Italy

    G. P. Velo

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© 1985 Plenum Press, New York

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Braquet, M., d’Onofrio, M., Garay, R., Braquet, P. (1985). Correlation Between K+ Fluxes and the Arachidonic Acid Cascade in Human Leukocyte Stimulated with a 23187 or Melittin. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_29

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  • DOI: https://doi.org/10.1007/978-1-4684-7841-9_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7843-3

  • Online ISBN: 978-1-4684-7841-9

  • eBook Packages: Springer Book Archive

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