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Nicotinic Cholinergic Receptors in Human Brain: Effects of Aging and Alzheimer

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Plasticity and Regeneration of the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 296))

Abstract

A review of studies on nicotinic cholinergic receptors in human brain is presented. The paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies from five different approaches are reported: a) molecular biology; b) receptor binding studies; c) studies with specific neurotoxins; d) immunocytochemistry; and e) PET scan. These studies document profound and characteristic differences between the normal aging and the pathological AD brain with regard to nicotinic cholinergic receptor localization, distribution and function.

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Authors and Affiliations

  1. Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, 62794, USA

    E. Giacobini

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  1. E. Giacobini
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Editors and Affiliations

  1. University of California, Berkeley, Berkeley, California, USA

    Paola S. Timiras

  2. Unité 336 INSERM, Université de Montpellier II, Montpellier, France

    Alain Privat

  3. Southern Illinois University, Springfield, Illinois, USA

    Ezio Giacobini

  4. University of North Carolina, Chapel Hill, North Carolina, USA

    Jean Lauder

  5. Health Sciences Center, University of Colorado, Denver, Colorado, USA

    Antonia Vernadakis

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© 1991 Plenum Press, New York

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Giacobini, E. (1991). Nicotinic Cholinergic Receptors in Human Brain: Effects of Aging and Alzheimer. In: Timiras, P.S., Privat, A., Giacobini, E., Lauder, J., Vernadakis, A. (eds) Plasticity and Regeneration of the Nervous System. Advances in Experimental Medicine and Biology, vol 296. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8047-4_28

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  • DOI: https://doi.org/10.1007/978-1-4684-8047-4_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8049-8

  • Online ISBN: 978-1-4684-8047-4

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