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Physiologic Models of Hepatic Drug Elimination

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New Trends in Pharmacokinetics

Part of the book series: NATO ASI Series ((NSSA,volume 221))

Abstract

Pharmacokinetic models are used primarily to describe the time course of drugs and metabolites in the body following various routes of administration. Such models take a variety of forms. Some are simply descriptive, comprising mathematical equations which make no reference to underlying physiology. The ability to use such descriptive models to interpret pharmacokinetic data and to predict outcome under a variety of conditions is extremely limited. Pharmacokinetic models which are physiologically based have greater application and have enjoyed wide usage, particularly those applied to the elimination of drugs by the liver and, to a lesser extent, by the kidneys [Rowland & Tozer, 1989]. The present chapter reviews the physiologic models that have been applied to hepatic clearance, focusing on recent advances, and comments on some problems and outstanding issues. Mention is also made of the usefulness of the isolated perfused liver for investigating drug distribution and elimination kinetics.

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Authors and Affiliations

  1. Department of Pharmacy, University of Manchester, Manchester, UK

    Malcolm Rowland & Allan M. Evans

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  1. Malcolm Rowland
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  2. Allan M. Evans
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Editors and Affiliations

  1. University of Parma, Parma, Italy

    Aldo Rescigno

  2. Hazleton Washington, Inc., Vienna, Virginia, USA

    Ajit K. Thakur

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© 1991 Plenum Press, New York

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Rowland, M., Evans, A.M. (1991). Physiologic Models of Hepatic Drug Elimination. In: Rescigno, A., Thakur, A.K. (eds) New Trends in Pharmacokinetics. NATO ASI Series, vol 221. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8053-5_6

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  • DOI: https://doi.org/10.1007/978-1-4684-8053-5_6

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