Abstract
Adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4.) catalyzes the irreversible hydrolytic deamination of adenosine to produce inosine and ammonia. Markedly reduced or absent adenosine deaminase activity in man is associated with an autosomal recessive form of severe combined immunodeficiency disease and the relationship appears to be causal.1,2,3,4 Affected patients present a defect of both cellular and humoral immunity characterized clinically by severe recurrent infections with a uniformly fatal outcome if untreated.
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© 1980 Plenum Press, New York
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Daddona, P.E., Frohman, M.A., Kelley, W.N. (1980). Radioimmunochemical Analysis of Human Erythrocyte Adenosine Deaminase. In: Rapado, A., Watts, R.W.E., De Bruyn, C.H.M.M. (eds) Purine Metabolism in Man—III. Advances in Experimental Medicine and Biology, vol 122B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8559-2_27
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DOI: https://doi.org/10.1007/978-1-4684-8559-2_27
Publisher Name: Springer, Boston, MA
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