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Transmitter Dynamics in the Carotid Body

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Chemoreceptors and Chemoreceptor Reflexes

Abstract

The classical studies of De Castro7 and Heymans et al.24 described the salient structural and sensory properties of the arterial chemosensory tissue of the mammalian carotid body. The elegant work of these early scholars set the state for contemporary research on chemoreception by focusing attention on type-I (glomus) cells in the carotid body. They suggested that these unusual cells act as preneural transducer elements which excite closely apposed afferent nerve terminals by releasing transmitter agents in response to natural stimuli. This fundamental tenet of carotid body physiology has endured numerous challenges for more than half a century, and today, following the discoveries of multiple neurotransmitter agents in type-I cells, it has emerged as a central theme in much of the current research activity on chemoreception. Indeed, the decade of the 1980’s ushered in a new and exciting era in carotid body research. The focus shifted from earlier controversies over the relative importance of type-I cells vs. sensory nerve endings, and whether acetylcholine or dopamine.was the chemosensory transmitter, to the present-day recognition that chemosensation very probably involves the concerted actions of multiple neuroactive agents, each of which plays a role in the generation and/or modulation of the chemosensory response. Although there is little consensus regarding the complex synaptic events which occur between type-I cells and afferent terminals, considerable progress has been made through the utilization of ever more powerful neurochemical and electrophysiological techniques and the development of greatly refined experimental preparations.

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Authors and Affiliations

  1. Department of Physiology, University of Utah School of Medicine, 410 Chipeta Way, Research Park, Salt Lake City, UT, 84108, USA

    S. Fidone, C. Gonzales, B. Dinger & L. Stensaas

Authors
  1. S. Fidone
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  2. C. Gonzales
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  3. B. Dinger
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  4. L. Stensaas
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Systemphysiologie, Dortmund, Federal Republic of Germany

    Helmut Acker

  2. Medical Academy, Warsaw, Poland

    Andrzej Trzebski

  3. University College, Dublin, Ireland

    Ronan G. O’Regan

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© 1990 Plenum Press, New York

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Fidone, S., Gonzales, C., Dinger, B., Stensaas, L. (1990). Transmitter Dynamics in the Carotid Body. In: Acker, H., Trzebski, A., O’Regan, R.G. (eds) Chemoreceptors and Chemoreceptor Reflexes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8938-5_1

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  • DOI: https://doi.org/10.1007/978-1-4684-8938-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8940-8

  • Online ISBN: 978-1-4684-8938-5

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