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Searching For the Function of Tissue Transglutaminase: Its Possible Involvement in the Biochemical Pathway of Programmed Cell Death

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Advances in Post-Translational Modifications of Proteins and Aging

Part of the book series: Advances in Experimental Medicine and Biology ((NATO ASI F,volume 231))

Abstract

Transglutaminases are Ca2+-dependent enzymes occurring widely in cells and body fluids (Folk and Chung, 1973; Chung, 1975; Folk, 1980). They catalyze the formation of ε(γ-glutamyl)lysine cross-links between proteins and γ-glutamylamine derivatives in proteins providing a potentially and functionally significant posttranslational modification (Folk and Finlayson, 1977; Folk et al., 1980). Three distinct forms have been studied most extensively, namely the catalytic (‘a’) subunit of blood coagulation factor XIII, the tissue transglutaminase and the keratinocyte enzyme. Studying the coagulation and the tissue enzyme remarkable progress has been made in our understanding of the catalytic mechanism of transglutaminases (Folk, 1983).

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  1. Department of Biochemistry and Department of Pathology, University School of Medicine, Debrecen, Hungary, H-4012

    Laszlo Fesus & Vilmos Thomazy

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  1. Laszlo Fesus
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  2. Vilmos Thomazy
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  1. University of Naples, Naples, Italy

    Vincenzo Zappia , Patrizia Galletti  & Raffaele Porta ,  & 

  2. University of Texas Health Science Center, Houston, Texas, USA

    Finn Wold

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Fesus, L., Thomazy, V. (1988). Searching For the Function of Tissue Transglutaminase: Its Possible Involvement in the Biochemical Pathway of Programmed Cell Death. In: Zappia, V., Galletti, P., Porta, R., Wold, F. (eds) Advances in Post-Translational Modifications of Proteins and Aging. Advances in Experimental Medicine and Biology, vol 231. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9042-8_10

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