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Molecular Heterogeneity of Luteinizing Hormone-Releasing Hormone

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Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

Following the structural elucidation of luteinizing hormone-releasing hormone (LH-RH) by Schally and associates, it became generally accepted that the decapeptide was a unique molecular form. This belief arose from:

  1. (a)

    A number of studies purporting to have shown non-ribosomal biosynthesis of LH-RH and thereby excluding the possibility of ribosomally biosynthesised prohormonal forms.

  2. (b)

    The assumption that LH-RH was confined to the CNS and thus unlikely to be present in other tissues in a modified form.

  3. (c)

    Immunological and low resolution chromatographic studies demonstrating that LH-RH in the hypothalamus of nonmammalian vertebrates was identical to the mammalian peptide. This conclusion of a lack of interspecific differences in LH-RH structure in vertebrates was supported by the demonstration that synthetic mammalian LH-RH was biologically active in a wide range of mammalian species and in nonmammalian vertebrates (1).

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Authors and Affiliations

  1. Department of Chemical Pathology, University of Cape Town Medical School, Observatory, 7925, South Africa

    Robert P. Millar & Judy A. King

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  1. Robert P. Millar
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  2. Judy A. King
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Editors and Affiliations

  1. International Foundation for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

  2. Weizmann Institute of Science, Rehovot, Israel

    Zvi Naor

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Millar, R.P., King, J.A. (1984). Molecular Heterogeneity of Luteinizing Hormone-Releasing Hormone. In: McKerns, K.W., Naor, Z. (eds) Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9960-5_30

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  • DOI: https://doi.org/10.1007/978-1-4684-9960-5_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9962-9

  • Online ISBN: 978-1-4684-9960-5

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