Abstract
The release of matrix Ca2+ from mitochondria is induced by a variety of compounds, eg. palmitoyl-CoA (P-CoA) (1). Addition of these compounds to mitochondria which contain Ca2+ produces a period of mitochondrial Ca2+ release and reaccumulation, i.e. Ca2+ cycling, followed by large amplitude swelling, inner membrane depolarization and net Ca2+ release (2). These phenomena occur only if inorganic phosphate is in the reaction medium (3). Whether these observations are related to the mechanism(s) through which the mitochondrion contributes to Ca2+ homeostasis in the normal cell remains to be determined. However, under pathological conditions such as ischemia this process of Ca2+ release may relate to matrix Ca2+ content and mitochondrial volume changes observed (4).
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© 1988 Plenum Press, New York
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Wolkowicz, P. (1988). Evidence for Hexagonal II Phase Lipid Involvement in Mitochondrial Ca2+ Movements. In: Pfeiffer, D.R., McMillin, J.B., Little, S. (eds) Cellular Ca2+ Regulation. Advances in Experimental Medicine and Biology, vol 232. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0007-7_15
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DOI: https://doi.org/10.1007/978-1-4757-0007-7_15
Publisher Name: Springer, Boston, MA
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