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The Physiology of Colonic Mucus Secretion

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Colon

Part of the book series: Topics in Gastroenterology ((TGEN))

Abstract

Physiological studies of the colon have focused basically on motility, water, and electrolyte absorption and secretion, but only occasionally on mucus secretion. Knowledge of the secretion of mucosubstances is scanty probably because of the enormous technical complexity required for its research. As with other organs, the quantity and quality of mucus secretion in the colon may be of major importance in pathology.

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References

  1. Bustos-Fernández L, Gonzalez E, Marzi A, et al: Fecal acidorrhea. N Engl J Med 284:295–298, 1971.

    Article  PubMed  Google Scholar 

  2. Bustos-Fernández L, Gonzalez E, Ledesma-Paolo MI, et al: Organic anions induce colonie secretion. Am J Dig Dis 21:329–332, 1976.

    Article  PubMed  Google Scholar 

  3. Ammon HV, Phillips S: Inhibition of colonic water and electrolyte absorption by fatty acids in man. Gastroenterology 65:744–749, 1973.

    PubMed  CAS  Google Scholar 

  4. Freeman JA: Goblet cell fine structure. Anat Rec 154:121–148, 1966.

    Article  PubMed  CAS  Google Scholar 

  5. Mekhjian HS, Phillips SF: Perfusion of the canine colon with unconjugated bile acids. Gastroenterology 59:120–129, 1970.

    PubMed  CAS  Google Scholar 

  6. Forth W, Rummel W, Glasner H: Zur resorptionshmmenden Wirkung von Gallensauren. Naunyn-Schmiedebergs Arch Pharmakol Exp Pathol 254:364–380, 1966.

    Article  PubMed  CAS  Google Scholar 

  7. Lewin MR, ElMasri SH, Clark CG: Effect of bile acids on mucus secretion in the dog colon. Eur Surg Res 11:392–398, 1979.

    Article  PubMed  CAS  Google Scholar 

  8. Yardley JH, Bayless TM, Luebbers EH, et al: Goblet cell mucus in the small intestine. Findings after net fluid production due to cholera toxin and hypertonic solutions. Johns Hopkins Med J 131:1–10, 1972.

    PubMed  CAS  Google Scholar 

  9. Donowitz H, Binder HJ: Effect of enterotoxins in Vibrio cholerae, Escherichia coli, and Shigella dysenteriae type 1 on fluid and electrolyte transport in the colon. J Infect Dis 124:135, 1976.

    Article  Google Scholar 

  10. Giannella RA, Gots RE, Charney AN, et al: Pathogenesis of salmonellosis mediated fluid secretion. Activation of adenylate cyclase and inhibition by indomethacin. Gastroenterology 69:1238–1245, 1975.

    PubMed  CAS  Google Scholar 

  11. Walker WA, Wu M, Bloch KJ: Stimulation by immune complexes of mucus release from the goblet cells of the rat small intestine. Science 197:370–372, 1977.

    Article  PubMed  CAS  Google Scholar 

  12. Lake AM, Blach KJ, Neutra MR, et al: Intestinal goblet cell mucus release.II. In vivo stimulation by antigen in the immunized rat. J. Immunol 122:834, 1979.

    PubMed  CAS  Google Scholar 

  13. Racusen LC, Binder HJ: Ricinoleic acid stimulation of active anion secretion in colonic mucosa of the rat. J Clin Invest 63:743–749, 1979.

    Article  PubMed  CAS  Google Scholar 

  14. Bright-Asare P, Binder HJ: Stimulation of colonic secretion of water and electrolytes by hydroxy fatty acids. Gastroenterology 64:81–88, 1973.

    PubMed  CAS  Google Scholar 

  15. Gaginella TS, Chadwick VS, Debongnie JC, et al: Perfusion of rabbit colon with ricinoleic acid: Dose-related mucosal injury, fluid secretion, and increased permeability. Gastroenterology 73:95–101, 1977.

    PubMed  CAS  Google Scholar 

  16. Donowitz M, Binder HJ: Effect of dioctyl sodium sulfo-succinate on colonic fluid and electrolyte movement. Gastroenterology 69:941–950, 1975.

    PubMed  CAS  Google Scholar 

  17. LaMont JT, Ventola A: Stimulation of colonic glycoprotein synthesis by dibutyryl cyclic AMP and theophyline. Gastroenterology 72:82, 1972.

    Google Scholar 

  18. Saunders DA, Sillery J, Rachmilewitz D, et al: Effect of bisacodyl on the structure and function of rodent and human intestine. Gastroenterology 72:849–856, 1977.

    PubMed  CAS  Google Scholar 

  19. Meisel JL, Bergman D, Graney D, et al: rectal mucosa proctoscopic and morphological changes caused by laxatives. Gastroenterology 72:1274–1279, 1977.

    PubMed  CAS  Google Scholar 

  20. Florey HW: The secretion of mucus and inflammation of mucous membranes, in Florey SH (ed): General Pathology. London, Lloyd-Luke Medical Books Ltd, 1962, pp 167–196.

    Google Scholar 

  21. Marshall T, Allen A: The isolation and characterization of the high molecular weight glycoprotein from pig colonic mucus. Biochem J 173:569–578, 1978.

    PubMed  CAS  Google Scholar 

  22. Forstner JF, Jabbal I, Findlay BP, et al: Interaction of mucus with calcium, H+ ion and albumin, in Forstner GG (ed): Modern Problem in Paediatrics. Basel, Karger, 1977, vol 19, p. 54.

    Google Scholar 

  23. Forstner JF: Intestinal mucus in health and disease. Digestion 17:234–263, 1978.

    Article  PubMed  CAS  Google Scholar 

  24. Jennings MA, Florey MW: Autoradiographic observations on the mucous cells of the stomach and intestine. QJ Exp Physiol 41:131–152, 1956.

    CAS  Google Scholar 

  25. Schachter H: The subcellular sites of glycosylation. Biochem Soc Symp 40:57, 1974.

    PubMed  CAS  Google Scholar 

  26. Schrager J, Oates MDG: The isolation and composition of the mayor glycoprotein from human gastric aspirates. Gut 12:559–569, 1971.

    Article  PubMed  CAS  Google Scholar 

  27. Allen A, Pain R, Snary D: Formation of mucous gel from the high moleculer weight mucoprotein of gastric mucosa. Discuss Faraday Soc 106:301–309, 1974.

    Google Scholar 

  28. Forstner J, Jabbal I, Forstner G: Goblet cell mucus of rat small intestine chemical and physical characterization. Can J Biochem 51:1154–1166, 1973.

    Article  PubMed  CAS  Google Scholar 

  29. Kramer MF, Geňze JJ, Strous GJAM: Site of synthesis, intracellular transport and secretion of glycoprotein in exocrine cells, in Ciba Foundation Symposium: Respiratory Tract Mucus. Amsterdam, Elsevier, 1978, p 25.

    Google Scholar 

  30. Kramer, MF, Poort C: Unstimulated secretion of protein from rat exocrine pancreas cells. J Cell Biol 73:533–547, 1977.

    Article  PubMed  CAS  Google Scholar 

  31. Gaginella TS, Phillips SF, Dozois RR, et al: Stimulation of adenylate cyclase in homogenates of isolated intestinal epithelial cells from hamsters. Gastroenterology 74:11–15, 1978.

    PubMed  CAS  Google Scholar 

  32. MacDermott RP, Donaldson RM, Trier JS: Glycoprotein synthesis and secretion by mucosal biopsies of rabbit colon and human rectum. J Clin Invest 54:545–554, 1974.

    Article  PubMed  CAS  Google Scholar 

  33. Lewis RW: Mucus globule membrane: An hypothesis concerning its role in determing the viscosity of mucus. J Theor Biol 61:21–25, 1976.

    Article  PubMed  CAS  Google Scholar 

  34. Elstein M: The proteins of cervical mucus and the influence of progestagens. J Obstet Gynaec Brit CWLTH 77:443, 1970.

    Article  CAS  Google Scholar 

  35. Powell DW, Tapper J: Intestinal ion transport cholinergic, β adrenergic interactions, in Binder HJ (ed): Mechanisms of Intestinal Secretion. Alan R. Liss Inc, New York, 1979, pp. 175–192.

    Google Scholar 

  36. Waldman DB, Gardner JD, Zfass AM, et al: Effects of vasoactive intestinal polypetide, secretin and related peptides on rat colonic transport and adenylate cyclase activity. Gastroenterology 73:518, 1977.

    PubMed  CAS  Google Scholar 

  37. Hultén L: In extrinsic nervous control of colonic motility and blood flow. Acta Physiol Scand suppl 335, 1969, p 49.

    Google Scholar 

  38. Fahrenkrug J, Haglund V, Jodal M, et al: Nervous release of vasoactive intestinal polypeptide in the gastrointestinal tract of cats: Possible physiological implications. J. Physiol 284:291, 1978.

    PubMed  CAS  Google Scholar 

  39. Avery Jones F: Foreword, in Elstein M, Parke DV (eds): Mucus in Health and Disease. New York, Plenum Press, 1977, pp. vii.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Instituto de Gastroenterología, “Dr. Jorge Perez Companc,”, Universidad Católica Argentina, Hospital Italiano, Buenos Aires, Argentina

    L. Bustos-Fernández, I. Ledesma-Paolo, J. Kofoed, E. Gonzalez, S. Hamamura, K. Ogawa-Furuya & C. Bernard

Authors
  1. L. Bustos-Fernández
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  2. I. Ledesma-Paolo
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  3. J. Kofoed
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  4. E. Gonzalez
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  5. S. Hamamura
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  6. K. Ogawa-Furuya
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  7. C. Bernard
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Editor information

Editors and Affiliations

  1. School of Medicine, Buenos Aires University, Buenos Aires, Argentina

    Luis Bustos-Fernández M.D.

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© 1983 Plenum Publishing Corporation

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Bustos-Fernández, L. et al. (1983). The Physiology of Colonic Mucus Secretion. In: Bustos-Fernández, L. (eds) Colon. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0307-8_4

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  • DOI: https://doi.org/10.1007/978-1-4757-0307-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0309-2

  • Online ISBN: 978-1-4757-0307-8

  • eBook Packages: Springer Book Archive

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