Abstract
During the last decade, adenosine deaminase (ADA) has attracted a great deal of attention because of its involvement in the development of the immune system. In humans, deficiency of ADA is usually associated with a hereditary form of severe combined immunodeficiency (Giblett et al., 1972). The largest amounts of enzyme have been found in lymphoid tissues, particularly in the thymus gland (Adams et al., 1976) and leukemic lymphoblasts of thymic phenotype (Smith et al., 1978). Within the thymus, ADA is predominantly located in cortical thymocytes (Chechik et al., 1981), which express higher enzyme activity than do medullary and extrathymic lymphocytes (Barton et al., 1979). These findings led to the suggestion that ADA is associated with the intrathymic differentiation of T cells.
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References
Adams, A,, and Harkness, R.A., 1976, Adenosine deaminase activity in thymus and other human tissues, Clin. Exp. Immunol. 26: 647.
Barton, R., Martiniuk, F., Hirschhorn, R., and Goldschneider, I., 1979, The distribution of adenosine deaminase among lymphocyte populations in the rat, J. Immunol. 122:216.
Chechik, B.E., and Minowada, J., 1979, Quantitation of human thymus-leukemia-associated antigen in established hematopoietic cell lines by radioimmunoassay, J. Nat. Canc. Inst. 63:609.
Chechik, B.E., Schrader, W.P., and Minowada, J., 1981, An immuno-morphologic study of adenosine deaminase distribution in human thymus tissue, normal lymphocytes, and hematopoietic cell lines, J. Immunol. 126:1003.
Chechik, B.E., and SenGupta, S., 1981, Detection of human, rat and mouse adenosine deaminase by immunochemical and immunomorphologic methods using antiserum to calf enzyme, J. Immunol. Meth. 45:165.
Gelfand, E.W., Lee, J.J., and Dosch, H.M., 1979, Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function, Proc. Nat. Acad. Sci. USA, 76:1998.
Giblett, E.R., Anderson, J.E., Cohen, F., Pollara, B., and Meuwissen, H.J., 1972, Adenosine deaminase deficiency in two patients with severely impaired cellular immunity, Lancet 2: 1067.
Lukes, R.J., and Collins, R.D., 1974, Immunologie characterization of human malignant lymphomas, Cancer 34:1488.
Macdermott, R.P., Tritsch, G.L., and Formeister, J.F., 1980, Adenosine deaminase and nucleoside phosphorilase activity in normal human blood mononuclear cell subpopulations, Clin. Exp. Immunol. 42:303.
Meuwissen, H.J., Pollara, B., and Pickering, R.J., 1975, Combined immunodeficiency disease associated with adenosine deaminase deficiency, J. Pediatr. 86:169.
Smith, J.F., Poplack, D.G., Holiman, B.J., Leventhal, B.G., and Yarbro, G., 1978, Correlation of adenosine deaminase activity with cell surface markers in acute lymphoblastic leukemia, J. Clin. Invest. 62:710.
Stein, H., Bonk, A., Tolksdorf, G., Lennert, K., Rodt, H., and Gerdes, J., 1980, Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin’s lymphomas, J. Histochem. Cytochem. 28:746.
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© 1984 Springer Science+Business Media New York
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Chechik, B., Schrader, W., Perets, A., Fernandes, B. (1984). Immunohistochemical Localization of Adenosine Deaminase in Human Lymphoid Tissues and Lymphomas. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0390-0_49
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DOI: https://doi.org/10.1007/978-1-4757-0390-0_49
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