Abstract
It has become increasingly clear that the accumulation of reactive intermediates in cells depends upon a delicate balance between activating and detoxifying enzymes and upon numerous other pharmacokinetic factors. The importance of conjugating enzymes such as UDP-gIucuronosyltransferase (GT), which uses nucleophilic substrates instead of reactive electrophiles, is only recently beginning to be recognized in toxicological studies. It has become obvious that nucleophilic intermediate metabolites of aromatic hydrocarbons are often further metabolized to ultimate carcinogens (Sims et al., 1974; Levin et al., 1978). Moreover, glucuronides may be stable transport forms of toxic intermediates which may be reactivated at a site distant from their formation (Kadlubar et al., 1977; Kinoshita and Gelboin, 1978; Mulder et al., 1978).
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Bock, K.W., Bock-Hennig, B.S., Lilienblum, W., Pfeil, H., Volp, R.F. (1982). Roles of Udp-Glucuronosyltransferase in the Inactivation of Benzo(a)Pyrene. In: Snyder, R., et al. Biological Reactive Intermediates—II. Advances in Experimental Medicine and Biology, vol 136. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0674-1_4
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