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Brain Iron Metabolism

Biochemical and Behavioral Aspects in Relation to Dopaminergic Neurotransmission

  • Chapter
Pathological Neurochemistry

Abstract

Three hundred years ago, Syndenham recognized the use of iron as a specific remedy for chlorosis, now recognized as iron-deficiency (ID) anemia. Thus, iron was the first trace element known to be essential, and is the most abundant trace element in the body.1 The relatively large amount of iron found in the brain is unevenly distributed and shows a close similarity to the distribution of dopamine (DA) in various regions. In the brain, as in the periphery, iron is associated with hemin, heme-containing enzymes, is found as nonheme iron in many enzymes and structural proteins, and is also important for protein synthesis.

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Authors and Affiliations

  1. Department of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion, Haifa, Israel

    M. B. H. Youdim

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  1. M. B. H. Youdim
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  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

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© 1985 Plenum Press, New York

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Youdim, M.B.H. (1985). Brain Iron Metabolism. In: Lajtha, A. (eds) Pathological Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0797-7_27

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  • DOI: https://doi.org/10.1007/978-1-4757-0797-7_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0799-1

  • Online ISBN: 978-1-4757-0797-7

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