Abstract
The effects of the sympathetic nerve stimulation and the administrations of sympathomimetics on the secretion of salivary kallikrein induced by the chorda tympani stimulation were examined quantitatively and qualitatively in the submandibular gland of the dog. The secretion of salivary kallikrein may be mediated through both adrenergic α- and β-receptors. The activities of salivary kallikrein secreted by either the chorda tympani stimulation or isoproterenol were riot inhibited by soy bean trypsin inhibitor in vitro, but those secreted by the sympathetic nerve stimulation and noradrenaline or adrenaline were markedly inhibited in vitro. These results suggested that secretion of glandular kallikrein was induced by the chorda tympani. stimulation and the sympathetic β-stimulation, and secretion of plasma kallikrein was induced by the sympathetic α-stimulation.
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References
Bdolah,A. and Schramm,M.,1965, The function of 3’,5’-cyclic AMP in enzyme secretion,Biochem.Biophys.Res.Commun.,18,452.
Beilenson,S.C.,Schachter,M. and Smaje,L.H.,1968,, Secretion of kallikrein and its role in vasodilatation in the submaxillary gland, J.Physiol., 199, 303.
Bhoola,K.D. and Ogle,C.W.,1966, The subcellular localization of kalli- krein, amylase and acetylcholine in the submaxillary gland of the guinea-pig,J.Physiol.,184,663.
Bhoola,K.D.,1968, Intracellular distribution of submaxillary kallikrein,J.Physiol.,196,431.
Emmelin,N.,Rolmberg,J. and Ohlin,P.,1965, Receptors for catechol amines in the submaxillary glands of rats,Brit.J.Pharmacol.,25,134.
Erdös,E.G.,Tague,L.L. and Miwa,I.,1968, Kallikrein in granules of the submaxillary gland,Biochem.Pharmacol.,17,667.
Gautvik,K.M.,Nustad,K. and Vystyd,J.,1969, Kininogenase activity in the stimulated submandibular salivary gland in cat,Scand.J.clin. Lab.Invest.,24,supp1. 107, 101.
Gautvik,K.,1970a, The interaction of two different vasodilator mechanisms in the Chorda-tympani activated submandibular salivary gland,Acta physiol.scand.,Y9,188.
GautvIk,K.,1970b, Parasympathetic neuroeffector transmission and functional vasodilatation in the submandibular salivary gland of cats,Acta physiol.scand.,79,204.
Gautvik,K.M.,Kriz,M. and Lund-Larsen,K.,1972a, Effects of alterations in calcium concentrations on secretion and protein synthesis in cat submandibular salivary gland,Acta physiol.scand.,85,418.
Gautvik,K.M.,Kriz,M. and Lund-Larsen,K.,1972b, Plasma kinins and adrenergic vasodilatation in the submandibular salivary gland of the cat,Acta physiol.scand.,86,419.
Gautvik,K.M.,Nustad,K. and Vystyd,J.,1972c, Kininogenase activity in the stimulated submandibular salivary gland in cats,Acta physiol. scand,85,438.
Gautvik,K.M.,Kriz,M.,Lund-Larsen,K. and Waaler,B.A.,1974, Sympathetic vasodilatation, kallikrein release and adrenergic receptors in the cat submandibular salivary gland,Acta physiol.scand.,90,438.
Hilton,S.M. and Lewis,G.P.,1956, The relationship between glandular activity, bradykinin formation and functional vasodilatation in the submandibular salivary gland,J.Physiol.,134,471.
Inoki,R.,Kudo,T.,Kotani,Y.,Oka,M.,Iwatsubo,K. and Matsumoto,K.,1978, Mechanism of substance P-induced salivary secretion in the rat, Proc.Kinin’78 Tokyo.
Malamud,D.,1972, Amylase secretion from mouse parotid and pancreas Role of cyclic AMP and isoproterenol,Biochim.Biophys.Acta,279,373.
Vogel,P. and We.rle,E.,1970, Kall.ihreïn inhibitors, in e Har,dbo Exper.Fha.rnncol.,Vo1.25,edited by Erdös,E.Ga,Springer-Verlag, Berlin,p.213.
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Kudo, T., Kotani, Y., Oka, M., Matsumoto, K., Inoki, R. (1979). Significance of Adrenergic α-Effect on Salivary Kallikrein Secretion in the Submandibular Gland of the Dog. In: Fujii, S., Moriya, H., Suzuki, T. (eds) Kinins—II. Advances in Experimental Medicine and Biology, vol 120. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0926-1_39
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DOI: https://doi.org/10.1007/978-1-4757-0926-1_39
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