Skip to main content

Human Thyroid Neoplasms Express ras p21 Protein at High Levels

  • Chapter
ras Oncogenes

Abstract

In vitro and in vivo studies on cell transformation have revealed that recognizable steps in the process of malignant cell transformation can be achieved >by quantitative and/or qualitative changes in proto-cmcogene expression (for a review see ref. 1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. D.A. Spandidos. A unified theory for the develo rent of cancer. Biosci. Rep. 6:691 (1986).

    Article  PubMed  CAS  Google Scholar 

  2. D.A. Spandidos and I.B. Kerr. Elevated expression of the hunan ras oncogene family in prema1 ignant and malignant tumors of the colorectum. Br. J. Cancer 49:681 (1984).

    Article  PubMed  CAS  Google Scholar 

  3. J.J. Slamon, J.B. Dekernion, I.M. Verna and M.J. Cline. Expression of cellular oncogenes in human malignancies. Science 224:256 (1984).

    Article  PubMed  CAS  Google Scholar 

  4. D.A. Spandidos and N.J. Agnantis. Htmnan malignant tumors of the breast as ca cared to their respective normal tissue have elevated expression of the Harvey ras oncogene. Anticancer Res. 4:269(1984).

    PubMed  CAS  Google Scholar 

  5. D.A. Spandidos, A. Lamothe and J.N. Field. Multiple transcriptional activation of cellular oncogenes in human head ana neck solid tirs. Anticancer Res. 5: 221 (1984).

    Google Scholar 

  6. A. R. W. Williams, J. Piris, D.A. Spandidos and A. H. Wyllie. Lrm nohistochemical detection of the ras oncogene p21 product in an experimental tumor and in human colorectal neoplasms. Br. J. Cancer 52: 687(1985).

    Article  PubMed  CAS  Google Scholar 

  7. N.J. Agnantis, C. Petraki, P. Markoulatos and D.A. Spandidos. Irro nohistochemical study of the ras oncogene expression in human breast lesions. Anticancer Res. 6: 1157(1986).

    PubMed  CAS  Google Scholar 

  8. M. Barbacid. Ras genes. Ann. Rev. Biochem. 56: 779 (1987).

    Article  PubMed  CAS  Google Scholar 

  9. J.L. Bos, E.R. Fearson, S.R. Hamilton, M. Barlaam-de Vries, J.H. Van Boom, A. van der Eb and B. Vogelstein. Prevalence of ras gene na tations in human colorectal cancers. Nature 327: 293(1987).

    Article  PubMed  CAS  Google Scholar 

  10. K. Forrester, C. Airroguera, K. Han, W. E. Grizzle and M. Perucho. Detection of high incidence of K-ras oncogenes during Inman colon tumorigenesis. Nature 327: 298(1987).

    Article  PubMed  CAS  Google Scholar 

  11. N.R. Learoine, E.S. Mayal l, F. S. Wyllie, C.J. Farr, D. Hughes, R.A. Padua, V. Thurston, E.D. Williams and D. Wynford-Thomas. Activated ras oncogenes in human thyroid cancers. Cancer Res. 48: 4459(1988).

    Google Scholar 

  12. O. Fasano, D. Birnbaum, L. Edl.und, J. Fogh and M. Wigler. New human transforming gene detected by a tuirorigenicity assay. Mol. Cell. Biol. 4:1695 (1984).

    PubMed  CAS  Google Scholar 

  13. K. Papadimitriou, M. Yiagnisis, G. Tolls and D.A. Spandidos. Irrn unohi stochanical analysis of the ras oncogene protein in human thyroid product thyroi neoplasms. Anticancer Res. In press.

    Google Scholar 

  14. M. E. Furth, L.J. Davis, B. Fleurdelys arrl E.M. Scolnick. Monoclonal antibodies to the p21 products of the transforming gene of Harvey mourine sarcoma virus of the cellular ras gene family. J. Viral. 43: 294(1982).

    CAS  Google Scholar 

  15. N. R. Lemine, E. Syall, F.S. Wyllie and D. Wynford-Teas. High frequency of ras oncogene activation in benign and malignant human thyroid tumors. InP “Ras oncogenes” D.A. Spandidos, ed., Plenum Publ. Co. New York (1989).

    Google Scholar 

  16. P. Terrier, Z.-M. Sheng, M. Schlumberger, M. Tubiana, B. Caillou, J.-P. Travagli, P. Fragu, C. Parmentier and G. Riou. Structure and expression of c-myc and c-fos proto-oncogenes in thyroid carcinomas. Br. J. Cancer 57: 43(1988).

    Article  PubMed  CAS  Google Scholar 

  17. R. Aasland, J.R. Lillehaug, R. Male, O. Josenaal, J.E. Varhaug and K. Kleppe. Expression of oncogenes in thyroid Murs: coexpression of c-erb2/neu and c-erbB. Br. J. Cancer 57: 358(1988).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer Science+Business Media New York

About this chapter

Cite this chapter

Yiagnisis, M., Papadimitriou, K., Spandidos, D.A. (1989). Human Thyroid Neoplasms Express ras p21 Protein at High Levels. In: Spandidos, D. (eds) ras Oncogenes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1235-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1235-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1237-7

  • Online ISBN: 978-1-4757-1235-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics