Abstract
A number of clinical trials are presently ongoing to test the utility of interferons (IFNs) as antiviral and antitumor agents; several tabulations of these have appeared and, in sum, these show that more trials are warranted (Reviewed in Ref. 1). Rather than reiterate these spotty pilot studies, I should like to consider the few key questions which should focus on the status of IFN trials.
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References
Stewart II, W. E. 1981. The Interferon System, 2nd Edition, Springer-Verlag, Vienna-New York.
Gresser, I. 1972. Antitumor effect of interferon. Adv. Cancer Res. 16: 97–140.
Strander, H., K. Cantell, P. A. Jakobsson, U. Nilsonne, G. Soderberg. 1974. Exogenous interferon therapy of osteogenic sarcoma. Acta Orthop. Scand. 45: 958–967.
Strander, H., K. Cantell, S. Ingimarsson, P. A. Jakobsson, U. Nilsonne, G. Soderberg. 1977. Interferon treatment of osteogenic sarcoma: a clinical trial. Fogarty Intern. Center Proc. 28: 377–380.
Strander, H. 1977. Interferons: anti-neoplastic drugs? Blut 35: 277–288.
Merigan, T. C., K. Skoro, J. H. Breeden, R. Levy, S. A. Rossenberg. 1978. Preliminary observations on the effect of human leukocyte interferon in non-Hodgkins lymphoma. N. Engl. J. Med. 299: 1444–1453.
Hill, N. O., L. Loeb, A. Pardue. 1978. Leukocyte interferon production and its effectiveness in acute lymphatic leukemia. J. Clin. Hematol. Oncol. 8: 66–70.
Ikic, D., Z. Markic, V. Orelic, B. Rode, P. Nola, K. Smudj, M. Knezevic and D. Jusic. 1981. Application of human leukocyte interferon in patients with urinary bladder papillomatosis, breast cancer and melanoma. Lancet I: 1022–1024.
Stewart II, W. E., I. Gresser, M. G. Tovey, M. T. Bandu and S. LeGoff. 1976. Identification of the cell-multiplication-inhibitory factors in interferon preparations as interferons. Nature 262: 300–303.
Gresser, I., C. Maury and D. Brouty-Boye. 1972. On the mechanism of the antitumor effect of interferon in mice. Nature 239: 167–168.
Gresser, I., M. T. Bandu and D. Brouty-Boye. 1974. Interferon and cell division. IX. Interferon-resistant L1210 cells: characteristics and origin. J. Natl. Cancer Inst. 52: 553–559.
Trinchieri, G., D. Santoli and H. Koprowski. 1978. Spontaneous cell-mediated cytotoxicity in humans: role of interferon and immunoglobulins. J. Immunol. 120: 1849–1860.
Lockart, R. Z. 1964. The necessity for cellular RNA and protein synthesis for viral inhibition from interferon. Biochem. Biophys. Res. Commun. 15: 513–518.
Chany, C., F. Fournier and S. Rousset. 1971. Potentiation of the antiviral activity of interferon by actinomycin D. Nature New Biology 230: 113–114.
Scott, G. M., J. Wallace, D. A. J. Tyrreu, K. Cantell, D. S. Sechar and W. E. Stewart II. 1982. An interim report on studies on the toxic effects of human leukocyte-derived interferon-alpha. J. Interferon Res. 2: 127–130.
Merigan, T. C. 1981. Personal couuuunication.
Petralli, J. K., T. C. Merigan and J. R. Wilbur. 1965. Circulating interferon after measles vaccination. New Engl. J. Med. 273: 198–201.
Stewart II, W. E. and J. Desmyter. 1975. Molecular heterogeneity of human leukocyte interferon. Virology 67: 68–78.
Streuli, M., A. Hau, W. Bou, W. E. Stewart II., S. Nagata and C. Weissmann. 1981. Target cell specificity of two species of human interferon produced in E. coli and hybrid molecules derived from them. Proc. Nat. Acad. Sci. USA. 78: 2848–2852.
Stewart II, W. E., P. DeSomer, V. G. Edy, K. Paucker, K. Berg and C. A. Ogburn. 1975. Distinct molecular species of human interferons: leukocyte and fibroblast. J. Gen. Virol. 26: 327–333.
Pazin G. J., M. Ho, H. Hoverkos, J. A. Armstrong, M. Breinig, H. Wechsler, A. Arvin, T. Merigan and K. Panteu. 1982. Effects of interferon-alpha on human warts. J. Interferon Res. 2: 235–244.
Strander, H. 1982. 3rd Annual International Congress for Interferon Research, Miami, Florida, November 1982.
Strander, H. 1977. Administration of exogenous interferon into patients with neoplastic diseases. Fifth Aharon KatzirKatchalsky Conference. Rehovot, Israel.
Borden, E. and collaborators. 1981. Second Annual International Congress for Interferon Research, San Francisco, California, October 1981.
Krown, S. 1982. 3rd Annual International Congress for Interferon Research. Miami, Florida, November 1982.
Nietheimmer, D. 1981. Personal communication.
Ikic, D., S. Smerdel, E. Soos and D. Jusic. 1975. Preliminary study of the use of interferon on condylomata acuminata in women, pp. 223–225. Proc. Symp. Clin. Use of Interferons. Yugoslay. Acad. Sci.
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Stewart, W.E. (1983). Interferons: Several Questions and Few Answers. In: Klein, T., Specter, S., Friedman, H., Szentivanyi, A. (eds) Biological Response Modifiers in Human Oncology and Immunology. Advances in Experimental Medicine and Biology, vol 166. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1410-4_2
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