Abstract
Among the primary risk factors of coronary heart disease (CHD), hypercholesterolemia, hypertension, and nicotine abuse take highest precedence. A total cholesterol level > 300 mg/dl signifies a high atherogenic risk for the person in question. However, hypercholesterolemia (> 300 mg/dl) is observed in only approximately 25% of all patients with CHD. The majority of CHD patients exhibit a total cholesterol level between 248 and 300 mg/dl. In correspondence with the results of the Framingham study, the distribution curve for total serum cholesterol in probands in whom CHD develops overlaps considerably with that in probands who exhibit no CHD; the average cholesterol value of probands suffering from CHD is 225 mg/dl (219 mg/dl in probands in whom CHD does not develop).1 With these results as a basis, it is not possible, in an individual case involving a total cholesterol level between 150 and 300 mg/dl, to make a statement regarding coronary risk.
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References
W. B. Kannel, W. P. Castelli and T. Gordon, Cholesterol in the prediction of atherosclerotic disease. New perspective based on Framingham study, Ann. Intern. Med. 90: 85 (1979).
G. Assmann, “Lipid Metabolism and Atherosclerosis,” Schattauer-Verlag, Stuttgart (1982).
G. Assmann, H. Schriewer, and K. H. Juchem, Zur Rolle des HDL-Cholesterins in der Präventivmedizin, Therapiewoch 31: 5563 (1981).
R. W. Mahley, Alterations in plasma lipoproteins induced by cholesterol feeding in animals including man, in: “Disturbances in Lipid and Lipoprotein Metabolism,” J. M. Dietschy, A. M. Gotto Jr., and J, A. Ontko, eds., American Physiological Society, Bethesda (USA) (1978).
W. Stoffel, O. Zierenberg, B. Tungal, and E. Schreiber, 13-C Nuclear magnetic resonance spectroscopic evidence for hydrophobic lipid-protein interactions in human high density lipoproteins, Proc. Natl. Acad. Sci. USA 71: 3696 (1974).
G. Assmann and H. Schriewer, Biochemie der high density lipoproteine, Klin. Wochenschr. 58: 749 (1980).
E. J. Schaefer and R. I. Levy, Composition and metabolism of high density lipoproteins, Prog. Biochem. Pharmacol. 15: 200 (1979).
E. J. Schaefer, S. Eisenberg, and R. I. Levy. Lipoprotein apoprotein metabolism, J. Lipid Res. 19: 667 (1978).
J. W. Gofman, W. Young, and R. Tandy, Ischemic heart disease, atherosclerosis and longevity, Circulation 34: 679 (1966).
Israel study: S. Yaari, U. Goldbourt, S. Even-Zohar, H. N. Neufeld, Association of serum high density lipoprotein and total cholesterol with total, cardiovascular, and cancer mortality in a 7-year prospective study of 10,000 men, Lancet 1: 1011 (1981).
J. J. Barboriak, A. J. Anderson, A. A. Rimm, and J. F. King, High density lipoprotein cholesterol and coronary artery occlusion, Metabolism 28: 735 (1979).
J. R. Milne, D. L. Stone, S. O. Banim, D. J. Galton, and R. S. O. Rees, High density lipoprotein and other risk factors for coronary artery disease assessed by angiography, Br. Med. J. 282: 1274 (1981).
J. O. Swanson, G. Pierpont, and A. Adicoff, Serum high density lipoprotein cholesterol correlates with presence but not severity of coronary artery disease, Am. J. Med. 71: 235 (1981).
D. R. Holmes Jr., L. R. Elveback, R. L. Frye, B. A. Kottke, and R. D. Ellefson, Association of risk factor variables and coronary artery disease documented with angiography, Circulation 63: 293 (1981).
G. Assmann, H. Funke, and H. Schriewer, The relationship of HDL-apolipoprotein A-I and HDL-cholesterol to risk factors of coronary heart disease. Initial results of the prospective epidemiological study in company employees in Westfalia, J. Clin. Chem. Clin. Biochem. 20: 287 (1982).
G. M. Kostner, P. Avogaro, G. Bittolo-Bon, G. Cazzalato, and G. B. Quinci, Determination of high-density lipoproteins: screening methods compared, Clin. Chem. 25: 939 (1979).
P. N. Herbert and L. D. Henderson, Plasma-triglycerides do not regulate high density lipoprotein concentration, Lancet 1: 1368 (1979).
P. Schwandt, Die Apolipoproteine, Klin. Wochenschr. 60: 637 (1982).
P. Avogaro, G. Bittolo-Bon, G. Cazzaloto, and E. Rorai, Relationship between apolipoproteins and chemical components of lipoproteins in survivors of myocardial infarction, Arteriosclerosis 37: 69 (1980).
G. DeBacker, M. Rosseneu, and J. P. Deslypere, Discriminative value of lipids and apoproteins in coronary heart disease, Atherosclerosis 42: 197 (1982).
R. G. Kladetzky, G. Assmann, S. Walgenbach, P. Tauchert, and H.-D. Helb, Lipid and apoprotein values in coronary angiography patients, Artery 7: 191 (1980).
J. J. Maciejko, D. R. Holmes, B. A. Kottke, A. R. Zinsmeister, D. M. Dinh, and S. Y. T. Mao, Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease, N. Engl. J. Med. 309: 385 (1983).
N. E. Miller, HDL-cholesterol, tissue cholesterol and coronary atherosclerosis. Epidemiological correlations, in “Atherosclerosis V: Proceedings of the 5th International Symposium,” A. M. Gotto Jr., L. C. Smith, and B. Allen, eds., Springer, New York (1980).
N. E. Miller, F. Hammett, S. Saltissi, S. Rao, H. Van Zeller, J. Coltart, and B. Lewis, Regulation of angiographically defined artery disease to plasma lipoprotein subfraction and apolipoproteins, Br. Med. J. 282: 1741 (1981).
H. Schriewer, H. Schulte, and G. Assmann, HDL phosphatidyl choline and risk factors of coronary heart disease. Prospective epidemiological study of company employees of Westfalia, (manuscript submitted).
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Assmann, G., Schriewer, H. (1984). High-Density Lipoproteins and Their Role in Preventing or Retarding Atherosclerosis. In: Malinow, M.R., Blaton, V.H. (eds) Regression of Atherosclerotic Lesions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1773-0_13
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DOI: https://doi.org/10.1007/978-1-4757-1773-0_13
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