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Colony Stimulating Factor-1 Stimulated Macrophage Membrane Protein Phosphorylation

  • Chapter
Biology of Growth Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 234))

Abstract

Colony Stimulating Factor-1 (CSF-1) is required for the in vitro survival, proliferation and differentiation of mononuclear phagocytes (precursor cell → monoblast → promonocyte → monocyte → macrophage) (reviewed in 1). Purified murine or human CSF-1 has been shown to be a hanodimer consisting of two identical ~ 14,000 Mr polypeptide chains that are maintained as a differ by disulfide bonds. It is heavily glycosylated with N-linked oligosaccharides of the acidic complex type. The variable molecular weight (Mr) of the native molecule within the range of 45,000–70,000 is entirely ascribable to variation in glycosylation. While the carbohydrate does not appear to be necessary for biological, antibody-binding, or receptor-binding activities, all of these activities are lost when the molecule is gently reduced to yield monomeric subunits2.

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Authors and Affiliations

  1. Department of Microbiology and Immunology and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, N.Y., 10461, USA

    Paul T. Jubinsky, Yee-Guide Yeung, Rosalba Sacca, Wei Li & E. Richard Stanley

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  1. Paul T. Jubinsky
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  2. Yee-Guide Yeung
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  3. Rosalba Sacca
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  4. Wei Li
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  5. E. Richard Stanley
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Editor information

Editors and Affiliations

  1. Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes Centre, University of Toronto General Hospital, Toronto, Ontario, Canada

    Jeffrey E. Kudlow

  2. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    David H. MacLennan

  3. Department of Medical Genetics and Medical Biophysics, University of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

    Alan Bernstein

  4. Department of Pathology and Banting and Best Diabetes Centre, University of Toronto and Toronto General Hospital General Hospital, Toronto, Ontario, Canada

    Avrum I. Gotlieb

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© 1988 Springer Science+Business Media New York

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Jubinsky, P.T., Yeung, YG., Sacca, R., Li, W., Stanley, E.R. (1988). Colony Stimulating Factor-1 Stimulated Macrophage Membrane Protein Phosphorylation. In: Kudlow, J.E., MacLennan, D.H., Bernstein, A., Gotlieb, A.I. (eds) Biology of Growth Factors. Advances in Experimental Medicine and Biology, vol 234. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1980-2_7

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  • DOI: https://doi.org/10.1007/978-1-4757-1980-2_7

  • Publisher Name: Springer, Boston, MA

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