Abstract
In mammalian cells, the adenylate cyclase is regulated by extracellular signaling molecules, hormones and neurotransmitters. This regulation involves specific transmembrane receptors and transducers which are heterotrimer G-proteins. In response to the liganded receptor the G-protein is activated by dissociation of the GTP-bound a subunit which can then activate the adenylate cyclase. Although this complex system which also involves negative regulatory circuit, has been extensively studied, the details of its functioning have not yet been completely elucidated.
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Jacquet, M., Camonis, J., Boy-Marcotte, E., Damak, F., Garreau, H. (1989). The Cyclic Amp Producing Pathway in Saccharomyces Cerevisiae Involves CDC25 and ras Genes Products. In: Bosch, L., Kraal, B., Parmeggiani, A. (eds) The Guanine — Nucleotide Binding Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2037-2_23
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DOI: https://doi.org/10.1007/978-1-4757-2037-2_23
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