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Vitamin D Receptor Translocation

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Vitamin D

Part of the book series: Nutrition and Health ((NH))

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Abstract

In eukaryotic cells, a constant exchange of ions, lipids, RNA, and proteins is carried out between the cytoplasm and nucleus. The nuclear envelope separates the nucleus from the cytoplasm, and the nuclear pore complex (NPC) is the site of exchange between the two compartments Small molecules may pass through the NPC by diffusion, but macromolecules that are larger than 20 kDa cannot enter the nucleus by passive diffusion. Transport of large proteins, such as the steroid receptors, into the nucleus is a multistep, highly regulated, time- and energy-dependent process [recently reviewed by Jans and Hubner (1)]. Protein import involves transport from the cytoplasm to the NPC, translocation through the NPC, and intranuclear targeting (Fig. 1).

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  1. Julia Barsony
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  1. Boston University Medical Center, Boston, MA, USA

    Michael F. Holick PhD, MD

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Barsony, J. (1999). Vitamin D Receptor Translocation. In: Holick, M.F. (eds) Vitamin D. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2861-3_8

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  • DOI: https://doi.org/10.1007/978-1-4757-2861-3_8

  • Publisher Name: Humana Press, Totowa, NJ

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