Abstract
Dopamine β-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine and thus is a hallmark protein of noradrenergic (NA) neurons. While DBH is largely co-expressed with tyrosine hydroxylase (TH) in NA and adrenergic neurons, DBH is not expressed in dopaminergic neurons. The highly restricted pattern of DBH expression in the nervous system (typically expressed in >0.0001% of the total neurons) predicts that this gene is subject to neuron-specific as well as to cell type-specific control mechanisms. Therefore, delineation of molecular mechanisms of DBH gene transcription may provide important insight to how NA phenotype is specified during neural development and how its abnormal regulation is related to brain disorders in which NA neurotransmission is dysregulated.
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© 2002 Springer Science+Business Media New York
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Kim, KS., Seo, H., Kim, C., Hwang, DY. (2002). Transcriptional Regulation of the Dopamine β-Hydroxylase Gene. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_27
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DOI: https://doi.org/10.1007/978-1-4757-3538-3_27
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