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Cytopathology of the Ovary

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Ovarian Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 107))

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Abstract

The ovaries are pelvic organs located bilaterally and attached to the uterine cornua and fallopian tubes by several ligaments that maintain their lateral location. There are various components of a normal ovary that are important to recognize. Many of these components undergo cyclical changes secondary to hormonal manifestations.

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References

  • Arey, L.B., The origin and form of the Brenner tumor. Am J Obstet Gynecol, 1961; 81: 74351.

    Google Scholar 

  • Beckstead, J.H., Alkaline phosphatase histochemistry in human germ cell neoplasia. Am J Surg Pathol, 1983; 7: 341–349.

    Article  PubMed  CAS  Google Scholar 

  • Bell, D.A. and R.E. Scully, Atypical and borderline endometrioid adenofibromas of the ovary. A report of 27 cases. Am J Surg Pathol, 1985; 9: 205–14.

    Article  PubMed  CAS  Google Scholar 

  • Berchuck, A., et al., Managing hereditary ovarian cancer risk. [Review]. Cancer 1999; 86 (11): 2517–24.

    Article  PubMed  CAS  Google Scholar 

  • Castilla, L.H., F.J. Couch, and M.R.e.a. Erdos, Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nature Genet. 1994; 2: 128–131.

    Google Scholar 

  • Clement, P.B., Blaustein’s pathology of the female genital tract. 4th edition ed. NY: Springer-Verlag, 1996.

    Google Scholar 

  • Commerci, J.T., et al., mature cystic teratoma: a clinocpathologic evaluation of 517 cases and review of the literature. Obstet Gynecol, 1994; 84: 22–28

    Google Scholar 

  • DePriest, P.D., E.R. Banks, and D.E.e.a. Powell, Endometrioid carcinoma of the ovary and endometriosis: the association in postmenopausal women. Gynecol Oncol, 1992; 47: 71–5.

    Article  PubMed  CAS  Google Scholar 

  • Easton, D.F., D. Ford, and D.T. Bishop, Breast cancer linkage consortium. Breast and ovarian cancer incidence in BRCA-1 mutation carriers. Am J Hum Genet., 1995; 56: 265–271.

    Article  PubMed  CAS  Google Scholar 

  • Erlich, C.E. and L. Roth, The Brenner tumor. A clinicopathologic study of 57 cases. Cancer, 1971; 27: 332–42.

    Article  Google Scholar 

  • Ford, D., et al., Breast cancer linkage consortium. Risk of cancer in BRCA1-mutation carriers. Lancet 1994; 343: 692–695.

    Article  PubMed  CAS  Google Scholar 

  • Frank, T.S. and A.M. Braverman, The pros and cons of genetic testing for breast and ovarian cancer risk (review). International Journal of Fertility and Reproductive Medicine 1999; 44 (3): 139–45.

    CAS  Google Scholar 

  • Fukunnaga, M., et al., Ovarian atypical endometriosis: its close association with malignant epithelial tumors. Histopathology, 1997; 30: 249–55.

    Article  Google Scholar 

  • Futreal, P.A., Q.Y. Liu, and D.E.A. Shattuck-Eldens, BRCA1 mutations in primary breast and ovarian carcinomas. Science 1994; 266: 120–122.

    Article  PubMed  CAS  Google Scholar 

  • Gompel, E. and S.G. Silverberg, Chapter 6, in Pathology in Gyneclogy and Obstetrics. J.B. Lippincott Company, 1994.

    Google Scholar 

  • Hall, J.M., M.K. Lee, and B.e.a. Newman, Linkage of early-onset familial breast cancer to chromosome 17g21. Science 1992: 1684–1689.

    Google Scholar 

  • Hart, W.R. and H.J. Norris, Borderline and malignant mucinous tumors of the ovary. Histologic riteria and clinical behavior. Cancer, 1973; 31 (5): 1031–45.

    Article  PubMed  CAS  Google Scholar 

  • Hendrickson, M.R., Surface epithelial neoplasms of the ovary, in State of the Art Reviews. Pathology. Hanley and Belfus: Philadelphia, 1992.

    Google Scholar 

  • Katsube, Y., J.W. Berg, and S.G. Silverberg, Epidemiologic pathology of ovarian tumors: a histopathologic review of primary ovarian neoplasms diagnosed in the Denver standard metropolital statistical area, 1 July–31 December 1969 and 1 July 31 December 1979. Int J Gynecol Pathol, 1982; 1: 3–16.

    Article  PubMed  CAS  Google Scholar 

  • Kline RC et al., Endometrioid carcinoma of the ovary: retrospective review of 145 cases. Gynecol Oncol, 1990; 39: 337–46.

    Article  PubMed  CAS  Google Scholar 

  • Koonings, P.P., et al., Relative frequency of primary ovarian neoplasms: a 10 year review. Obstet Gynecol, 1989; 74: 921–926.

    PubMed  CAS  Google Scholar 

  • Kurman, R.J. and H.J. Norris, Malignant mixed germ cell tumors of the ovary. A clinical and pathologic analysis of 30 cases. Obstet Gynecol, 1976; 48: 579–589.

    PubMed  CAS  Google Scholar 

  • Kurman, R.J. and H.J. Norris, Embryonal carcinoma of the ovary: a clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis. Cancer, 1976; 38: 2420–2433.

    Article  PubMed  CAS  Google Scholar 

  • Lee, W.Y., et al., Immuno-localization of BRCA1 protein in normal breast tissue and sporadic breast invasive ductal carcinomas: a correlation with other biological parameters. Histopathology, 1999; 34: 106–112.

    Article  PubMed  CAS  Google Scholar 

  • Mostoufizadeh, M. and R.E. Sculley, Malignant tumors arising in endometriosis. Clin Obstet Gynecol, 1980; 23: 951–63.

    PubMed  CAS  Google Scholar 

  • McKay D.G., et al., The adult human ovary, a histochemical study. Obstet and Gynecol, 1961; 18: 13–39.

    CAS  Google Scholar 

  • Nogales, F.F., et al., Immature teratoma of the ovary with neural component (solid teratoma): A clinicopathologic study of 20 cases. Hum Pathol, 1976; 7: 625–642.

    Article  PubMed  Google Scholar 

  • O’Connor, D.M. and H.J. Norris, The influence of grade on the outcome of stage 1 ovarian immature (malignant) teratomas and the reproducibility of grading. Int J Gynecol Pathol, 1994;

    Google Scholar 

  • Oliva, E., et al., Ovarian carcinomas with choriocarcinomatous differentiation. Cancer, 1993; 72: 2441–2446.

    Article  PubMed  CAS  Google Scholar 

  • Peterson, F. Annual report of treatment in gynecological cancer. in International Federation of Gynecology and Obstetrics.Stockholm, 1999.

    Google Scholar 

  • Scully, E.R., R.H. Young, and P.B. Clement, Tumors of the ovary, maldeveloped gonads, fallopian tubes and broad ligament. third series ed. Atlas of tumor pathology. Vol. 23. 1998: AFIP.

    Google Scholar 

  • Shih, I. and R. Kurman, Immunohistochemical localization of inhibin alpha in the placenta and gestational trophoblastic lesions. Intl J of Gyecol path, 1999; 18 (2): 144–150.

    Article  CAS  Google Scholar 

  • Simard, L., Polyembryonic embryoma of the ovary of pathogenic origin. Cancer, 1957; 10: 215–223.

    Article  PubMed  CAS  Google Scholar 

  • Reagan, JW., Ceroid pigment in the human ovary. Am. J Obstet Gynecol, 1950; 59: 433–436. Ruffner, H. and I.M. Verma, BRCAI is a cell cycle-regulated nuclear phosphoprotein. Natl Acad Sci. 1997; 94: 7138–7143.

    Google Scholar 

  • Russell, P. and A. Farnsworth, Surgical pathology of the ovaries. second edition ed. United kingdom: Churchhill Livingstone, 1997.

    Google Scholar 

  • Russell, P., Blaustein’s pathology of the female genital tract. 4th edition ed. NY: Springer-Verlag, 1996.

    Google Scholar 

  • Russell, P., The pathological assessment of ovarian neoplasms: I: Introduction to the common ‘epithelial’ tumors and analysis of benign ‘epithelial’ tumors. Pathology, 1979. 11: 493–532.

    CAS  Google Scholar 

  • Sasaki, H., M. Furusato, and S.e.a. Teshima, Prognostic significance of histopathologic subtypes in stage I pure yolk sac tumor of the ovary. British J Cancer, 1994; 69: 529–536.

    Article  CAS  Google Scholar 

  • Shen, D. and J.V. Vadgama, BRCA1 amd BRCA2 gene mutation analysis: visit to the breast cancer information core (BIC). Oncology Research, 1997; 11 (2): 63–9.

    Google Scholar 

  • Smith, T.E., Meeting to sort out BRCA1 confusion. Science 1996. 272: p. 799.

    Article  Google Scholar 

  • Snyder, R.R., H.J. Norris, and F. Tavassoli, Endometrioid proliferative and low malignant potential tumors of the ovary. A clinicopathologic study of 46 cases. Am J Surg Pathol, 1988; 12: 661–71.

    Article  PubMed  CAS  Google Scholar 

  • Telium, G., Endodermal sinus tumors of the ovary and testis. comparative morphogenesis of the so-called mesonephroma ovarii (Schiller) and extraembryonic (yolk sac-allantoic) structures of rat placenta. Cancer, 1959; 12: 1092–1105.

    Article  Google Scholar 

  • Wang, H., et al., BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCAIa, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. Oncogene 1997; 15: 143–157.

    Article  PubMed  CAS  Google Scholar 

  • Wojcik, E.M. and B. Naylor, “Collagen balls” in peritoneal washings. Acta cytologica, 1992; 46: 466–470.

    Google Scholar 

  • Zaloudek, C.J., F.A. Tavassoli, and H.J. Norris, Dysgerminoma with syncytiotrophoblastic cells. A histologically and clinically distinctive subtype of dysgerminoma. Am J Surg Pathol, 1981; 5: 361–367.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, H.T., X. Zhang, and H.Z.e.a. Zhao, Relationship of p215BRCAI to tyrosine kinase signaling pathways and the and the cell cycle in normal and transfomed cells. Oncogene 1997; 14: 2863–2869.

    Article  PubMed  CAS  Google Scholar 

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DeFrias, D.V.S., Okonkwo, A.M., Keh, P.C., Nayar, R. (2002). Cytopathology of the Ovary. In: Ovarian Cancer. Cancer Treatment and Research, vol 107. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3587-1_8

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  • DOI: https://doi.org/10.1007/978-1-4757-3587-1_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-3589-5

  • Online ISBN: 978-1-4757-3587-1

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