Abstract
The growth of human T lymphocytes can be divided into two discrete stages resembling competence and progression. In the first stage, the binding of antigen or mitogen to specific T cell receptors triggers the transduction of intracellular signals leading to cellular activation1,2. In turn, these activation signals induce the de novo expression of genes mediating T cell growth including interleukin-2 (IL-2) and interleukin-2 receptors (IL-2R)3–5. The subsequent binding of IL-2 to its high affinity receptor promotes proliferation and clonal expansion of the cells originally stimulated by antigen.
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Greene, W.C., Böhnlein, E., Siekevitz, M., Ballard, D.W., Franza, B.R., Lowenthal, J.W. (1989). Structure and Regulation of the Human IL-2 Receptor. In: Gupta, S., Paul, W.E. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5803-0_7
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DOI: https://doi.org/10.1007/978-1-4757-5803-0_7
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