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Structure and Localization of Gangliosides

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Neurobiology of Glycoconjugates

Abstract

Gangliosides are sialic acid-containing glycosphingolipids (GSLs) found primarily in the plasma membrane of virtually all vertebrate tissues and are particularly abundant in the nervous system. They constitute part of the glycocalyx network surrounding the cell surface and are crucial in determining the properties and functions of cells. Structurally, they contain a hydrophobic ceramide chain to which a hydrophilic oligosaccharide is glycosidically linked. Some representative brain gangliosides are shown in Figure 1.

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  1. Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, 23298, USA

    Robert K. Yu & Megumi Saito

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  1. Department of Pharmacology, New York University Medical Center, 10016, New York, New York, USA

    Richard U. Margolis

  2. Department of Pharmacology, State University of New York, Health Science Center at Brooklyn, 11203, Brooklyn, New York, USA

    Renée K. Margolis

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Yu, R.K., Saito, M. (1989). Structure and Localization of Gangliosides. In: Margolis, R.U., Margolis, R.K. (eds) Neurobiology of Glycoconjugates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5955-6_1

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