Skip to main content

Sensing Improvement of Protein C Biosensor by Sample Circulation

  • Conference paper
Oxygen Transport to Tissue XXV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 540))

Abstract

Protein C (PC) is one of the most important proteins involved in the blood hemostasis. It is a potent anticoagulant, antithrombotic, and anti-inflammatory agent. Individuals with heterozygous PC deficiency have, by the age of 40, an 8–10 times higher risk of the thrombotic complications1. Accordingly, PC deficiency may lead to problems of oxygen and nutrient transport to tissue. Therefore, early diagnosis of PC deficiency is crucial to prevent thrombo-embolic episodes, such as, lung embolism, stroke, and/or heart attack.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Markis, M., Rosendaal, F. R., and Preston, F. E., Familial thrombophiloa: genetic risk factors and management, J. Internal Medicine 242 (Suppl. 740), 9–15 (1997).

    Google Scholar 

  2. Colman, R. W., Hirsh, J., Marder, V. J., and Salzman, E. W., Hemostasis and Thrombosis: basic principles and clinical practive, 3rd ed. ( J.B. Lippincott Company, Philadelphia, 1993 ), p. 262.

    Google Scholar 

  3. Spiker, J. O., Kang, K. A., Drohan. W. N., and Bruley, D. F., Protein C detection via fluorophore mediated immuno-optical biosensor, Adv. Exp. Med. Biol. 428, 621–627 (1997).

    Article  PubMed  CAS  Google Scholar 

  4. Spiker, J. O., Preliminary study of a fiber-optic based protein C biosensor utilizing fluorophore mediated immunological methods, MS Thesis, Chemical Engineering, University of Maryland Baltimore County, Maryland, (1999a).

    Google Scholar 

  5. Kwon, H. J., Theoretical and experimental investigation on sensing performance of Protein C immunooptical sensor for physiological samples, PhD dissertation, Chemical Engineering, University of Louisville, Louisville, KY, (2002)

    Google Scholar 

  6. Spiker, J. O. and Kang, K. A., Preliminary study of real-time fiber optic based protein C biosensor, Biotech. Bioeng. 66 (3), 158–163, (1999b).

    Article  CAS  Google Scholar 

  7. Spiker, J. O., Kang, K.A., Drohan. W. N., and Bruley, D. F., Preliminary study of biosensor optimization for the detection of protein C, Adv. Exp. Med. Bio!. 454, 681–688, (1998).

    Article  CAS  Google Scholar 

  8. Balcer, H. I., Spiker, J. O., and Kang, K. A., Sensitivity of a protein C immuno-sensor with and without human serum albumin, Adv. Exp. Med. Bio. 471, 605–612, (1999).

    Article  CAS  Google Scholar 

  9. Balcer, H. I., Studies of Protein C Biosensor Performance for Physiological Samples, MSThesis, Biological Science, University of Maryland Baltimore County, Maryland (2000).

    Google Scholar 

  10. Balcer, H. I., Kwon, H. J., and Kang, K. A., Assay procedure optimization of rapid, reusable protein immunosensor for physiological samples, Ann. Biomed. Eng. 30 (10), 141–147, (2002).

    Article  PubMed  Google Scholar 

  11. Spiker, J. O., Drohan, W. N., and Kang, K. A., Reusability study of fiber optic based protein C biosensor, Adv. Exp. Med. Bio!. 471, 731–739, (1999a).

    Article  CAS  Google Scholar 

  12. Kwon, H. J., Balcer, H. I., and Kang, K. A., Sensing performance of protein C immuno-biosensor for biological samples and sensor minimization, Comparative Biochem. Phys., part A 132, 231–238, (2002).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this paper

Cite this paper

Tang, L., Kang, K.A. (2003). Sensing Improvement of Protein C Biosensor by Sample Circulation. In: Thorniley, M., Harrison, D.K., James, P.E. (eds) Oxygen Transport to Tissue XXV. Advances in Experimental Medicine and Biology, vol 540. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6125-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6125-2_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3428-4

  • Online ISBN: 978-1-4757-6125-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics