Skip to main content

Selenium in health and disease IV

Selenium and the immune response

  • Chapter
Selenium in Food and Health

Abstract

The immune system is a collection of tissues, cells and molecules whose prime physiological function is protection of the body against harmful influences, both internal and external, which can damage health. It is also involved in other functions such as wound healing and the removal of cells that die through natural processes. In a restricted sense immunity refers to mechanisms established by a host to resist disease after exposure to a foreign infectious agent. In a broader sense it can also include hypersensitive biological phenomena of altered tissue reactivity such as allergies, acquired tolerance to and rejection of foreign tissues and autoimmune diseases.1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Maurer, P.H. (1961) Immunology, in Encyclopedia of the Biological Sciences (ed. Gray, P.), Reinhold, New York, pp. 503–5.

    Google Scholar 

  2. Staines, N.A., Brostoff, J. and James, K. (1993) Introducing Immunology, 2nd edn., Mosby, St. Louis.

    Google Scholar 

  3. Montgomery, R., Dryer, R.L., Conway, T.W. and Spector, A.A. (1977) Biochemistry, a Case-Oriented Approach, 2nd edn., Mosby, St. Louis, pp. 65–7.

    Google Scholar 

  4. Nossal, G.J.V. (1969) Antibodies and Immunity, Basic Books, New York.

    Google Scholar 

  5. Larsen, H.J.S. (1993) Relations between selenium and immunity. Norwegian Journal of Agricultural Sciences, Suppl. 11, 105–119.

    Google Scholar 

  6. Kiremidjian-Schumacher, L.R. and Stotzky, G. (1987) Selenium and immune responses. Environmental Research, 42, 277–303.

    Article  CAS  Google Scholar 

  7. Turner, R.J. and Finch, J.E. (1991) Selenium and the immune response. Proceedings of the Nutrition Society, 50, 275–85.

    Article  CAS  Google Scholar 

  8. Marsh, J.A., Combs, G.F., Whiteacre, M.E. and Dietert, R.R. (1986) Effect of selenium and vitamin E dietary deficiencies on chick lymphoid organ developments. Proceedings of the Society for Experimental Biology and Medicine, 182, 425–36.

    CAS  Google Scholar 

  9. Mulhern, S.A., Taylor, G.L., Magruder, L.E. and Vessey, A.R. (1985) Deficient levels of dietary selenium suppress the antibody response in first and second generation mice. Nutrition Research, 5, 201–10.

    Article  CAS  Google Scholar 

  10. Spallholz, J.E., Martin, J.L., Gerlach, M.L. and Heinzerling, R.H. (1975) Injectable selenium: effect on the primary immune response of mice. Proceedings of the Society for Experimental Biology and Medicine, 148, 37–40.

    CAS  Google Scholar 

  11. Larsen, H.J., Moksnes, K. and Overnes, G. (1988) Influence of selenium on antibody production in sheep. Research in Veterinary Science, 45, 4–10.

    CAS  Google Scholar 

  12. Blodgett, D.J., Schurig, G.G., Kornegay, E.T., et al. (1989) Failure of an enhanced dietary selenium concentration to stimulate humoral immunity in gestating swine. Nutrition Reports International, 40, 543–50.

    CAS  Google Scholar 

  13. Arvilommi, H., Poikonen, K., Jokinen, I., et al. (1983) Selenium and immune functions in humans. Infection and Immunity, 41, 185–9.

    CAS  Google Scholar 

  14. Marsh, J.A., Dietert, R.R. and Combs, G.F. (1987) Effect of dietary selenium and vitamin E deficiencies in the chicken on Con A-induced splenocyte proliferation. Progress in Clinical and Biological Research, 238, 333–45.

    CAS  Google Scholar 

  15. Larsen, H.J. and Tollersrud, S. (1981) Effect of dietary vitamin E and selenium on the phytohaemogglutinin response of pig lymphocytes. Research in Veterinary Science, 31, 301–5.

    CAS  Google Scholar 

  16. Eskew, M.L., Scholz, R.W., Reddy, C.C., et al. (1985) Effects of vitamin E and selenium deficiencies on rat immune function. Immunology, 54, 173–80.

    CAS  Google Scholar 

  17. Turner, R.J. and Finch, J.M. (1990) Immunological malfunctions associated with low selenium-vitamin E diets in lambs. Journal of Comparative Pathology, 102, 99–109.

    Article  CAS  Google Scholar 

  18. Whanger, P.D., Weswig, P.H. and Oldfield, J.E. (1978) Selenium, sulfur and nitrogen levels in ovine rumen microorganisms. Journal of Animal Science, 46, 515–9.

    CAS  Google Scholar 

  19. Burk, R.F. (1989) Newer roles of selenium in nutrition. Journal of Nutrition, 119, 1051–4.

    CAS  Google Scholar 

  20. Khalil, A.M. (1989) The induction of chromosome aberrations in human purified peripheral blood lymphocytes following in vivo exposure to selenium. Mutation Research, 224, 503–6.

    Article  CAS  Google Scholar 

  21. Spallholz, J.E., Martin, J.L., Gerlach, M.L. and Heinzerling, R.H. (1973) Enhanced immunoglobulin M and immunoglobulin G antibody titres in mice fed selenium. Infection and Immunity, 8, 841–2.

    CAS  Google Scholar 

  22. Roy, M., Kiremidijian-Schumacher, L., Wishe, H.I., et al. (1990) Selenium and immune cell functions. 2. Effect on lymphocyte-mediated cytotoxicity. Proceedings of the Society for Experimental Biology and Medicine, 193, 143–8.

    CAS  Google Scholar 

  23. Koller, L.D., Exon, J.H., Talcott, P.A., et al. (1986) Immune response in rats supplemented with selenium. Clinical and Experimental Immunology, 63, 570–6.

    CAS  Google Scholar 

  24. Kirmidjian-Schumacher, L., Roy, M., Wishe, H.I., et al. (1990) Selenium and immune cell functions. 1. Effects of lymphocyte proliferation and production of interleukin 1 and interleukin 2. Proceedings of the Society for Experimental Biology and Medicine, 193, 136–42.

    Google Scholar 

  25. Collins, R.J., Boyle, P.J., Battistutta, D., et al. (1991) In vitro OKT3-induced mitogenesis in selenium deficient patients on a diet for phenylketonuria. Biological Trace Elements Research, 30, 233–44.

    Article  CAS  Google Scholar 

  26. Reilly, C., Barrett, J., Patterson, C., et al. (1990) Trace element nutritional status and dietary intake of children with phenylketonuria. American Journal of Clinical Nutrition, 52, 159–65.

    CAS  Google Scholar 

  27. Boyne, R., Mann, S.O. and Arthur, J. (1984) Effects of Salmonella typhimurium infection on selenium deficient rats. Microbios Letters, 27, 83–7.

    Google Scholar 

  28. Boyne, R. and Arthur, J.R. (1986) The response of selenium-deficient mice to Candida albicans infection. Journal of Nutrition, 116, 816–22.

    CAS  Google Scholar 

  29. Serfass, R.E. and Ganther, H.E. (1975) Defective microbiocidal activity in glutathione peroxide deficient neutrophils of Se deficient rats. Nature (London), 225, 640–1.

    Article  Google Scholar 

  30. Arthur, J.R. and Boyne, R. (1985) Superoxide dismutase and glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle. Life Science, 36, 1569–75.

    Article  CAS  Google Scholar 

  31. Arthur, J.R., Boyne, R., Hill, H.A. and Okolow-Zubkowska, M.J. (1981) The production of oxygen-derived radicals by neutrophils from selenium-deficient cattle. FEBS Letters, 135, 187–90.

    Article  CAS  Google Scholar 

  32. Murray, J.M. and Murray, A.B. (1985) The effects of selenium deficiency and repletion on host resistance to infection, in Trace Element Metabolism in Man and Animals—TEMA 5 (ed. Mills, C.F., Bremner, I. and Chesters, J.K.), Commonwealth Agricultural Bureaux, Cambridge, pp. 244–7.

    Google Scholar 

  33. Boyne, R., Mann, S.O. and Arthur, J.R. (1984) Effects of Salmonella typhimurium infection on selenium deficient rats. Microbios Letters, 27, 83–7.

    Google Scholar 

  34. Levander, O.A., Ager, A.L., Jr., and Beck, M.A. (1995) Vitamin E and selenium: contrasting and interacting nutritional determinants of host resistance to parasitic and viral infections. Proceedings of the Nutrition Society, 54, 475–87.

    Article  CAS  Google Scholar 

  35. Peretz, A., Neve, J., Duchateau, V., et al. (1991) Effect of selenium supplementation on immune parameters in gut failure patients on home parenteral nutrition. Nutrition, 7, 215–21.

    CAS  Google Scholar 

  36. Peretz, A. (1994) Selenium inflammatory and immune processes: some recent clinical applications [Abstract], Selenium-Tellurium Development Association, 5th International Symposium, Brussels, 8–10 May.

    Google Scholar 

  37. Simonoff, M., Sergeant, C., Razafindrabe, L., et al. (1993) Plasma trace element levels in 89 HIV infected patients: correlation with nutritional and immunological status, in Trace Elements in Man and Animals—TEMA 8 (ed. Anke, M., Meissner, D. and Mills, C. F.), Verlag Media Touristik, Gersdorf, pp. 768–71.

    Google Scholar 

  38. Mantero-Atienza, E., Sotomayor, M.G., Shor-Posner, G., et al. (1991) Selenium status and immune function in asymptomatic HIV-1 seropositive men. Nutrition Research, 11, 1237–50.

    Article  Google Scholar 

  39. Golden, H.M.N. and Ramdath, D. (1987) Free radicals in the pathogenesis of kwashiorkor. Proceedings of the Nutrition Society, 46, 53–68.

    Article  CAS  Google Scholar 

  40. Golden, M.H.N. (1985) The consequences of protein deficiency in man and its relationship to the features of kwashiorkor, in Nutritional Adaptation in Man (ed. Blaxter, K. and Waterlow, J.C.), Applied Science, London, pp. 169–87.

    Google Scholar 

  41. Gopalan, G. (1968) Kwashiorkor, in Calorie Deficiencies and Protein Deficiency (ed. McCance, R.A. and Widdowson, E.M.), Churchill, London, pp. 48–58.

    Google Scholar 

  42. Hendrickse, R.G. (1984) Aflatoxin intoxication and kwashiorkor. Transactions of the Royal Society of Tropical Medicine and Hygiene, 78, 427–35.

    Article  CAS  Google Scholar 

  43. Burk, R.F., Pearson, W.N., Wood, R.P. and Viteri, F. (1967) Blood selenium levels and in vitro red blood cell uptake of 75Se in kwashiorkor. American Journal of Clinical Nutrition, 20, 723–30.

    CAS  Google Scholar 

  44. Sive, A.A., Heese, H. de V., Dempster, W.S., et al. (1991) Protein energy malnutrition: selenium, glutathione peroxidase and glutathione in children with acute kwashiorkor and during refeeding, in Trace Elements in Man and Animals—TEMA 7 (ed. Momcilovic, B.), IMI, Zagreb, pp. 19.15–19.16.

    Google Scholar 

  45. Paynter, D.I. (1979) Glutathione peroxidase and selenium in sheep. 1. Effects of intraruminal selenium pellets on tissue glutathione peroxidase activities. Australian Journal of Agricultural Research, 30, 695–702.

    Article  CAS  Google Scholar 

  46. Behne, D. and Höfer-Bosse, T. (1984) Effects of a low selenium status on the distribution and retention of selenium in the rat. Journal of Nutrition, 114, 1289–96.

    CAS  Google Scholar 

  47. Burk, R.F. (1988) Selenium deficiency in search of a disease. Hepatology, 8, 421–3.

    Article  Google Scholar 

  48. Casey, C.E. (1988) Selenophilia. Proceedings of the Nutrition Society, 47, 55–62.

    Article  CAS  Google Scholar 

  49. Reilly, C. (1993) Selenium in health and disease: a review. Australian Journal of Nutrition and Dietetics, 50, 136–44.

    Google Scholar 

  50. Anon. (1993) Oxidative stress and human disease: a broad spectrum of effects. Antioxidant Vitamins Newsletter, Hoffman-La Roche, New York, No. 7, 12.

    Google Scholar 

  51. Sperduto, R.D., Ferris, F.L. and Kurinij, N. (1990) Do we have a nutritional treatment for age-related cataract or macular degeneration? Archives of Ophthalmology, 108, 1403–5.

    Article  CAS  Google Scholar 

  52. Eye Disease Control Study Group (1993) Antioxidant status and neovascular age-related macular degeneration. Archives of Ophthalmology, 111, 104–9.

    Article  Google Scholar 

  53. Noell, W.K., Laker, V.S., Kang, B.S. and Berman, S. (1966) Retinal damage by light in rats. Investigative Ophthalmology, 5, 450–73.

    CAS  Google Scholar 

  54. Young, R.W. (1988) Solar radiation and age-related macular degeneration. Survey of Ophthalmology, 32, 252–69.

    Article  CAS  Google Scholar 

  55. Weiter, J., Dratz, E., Fitch, K. and Handelman, G. (1985) Role of selenium nutrition in senile macular degeneration [Abstract]. Investigative Ophthalmology and Visual Science, 26 (Suppl.), 58.

    Google Scholar 

  56. Sanders, T.A.B. (1993) Plasma cholesterol, and fat soluble vitamins in subjects with age-related maculopathy and matched control subjects. American Journal of Clinical Nutrition, 57, 428–33.

    CAS  Google Scholar 

  57. Varma, S.D. (1991) Scientific basis for medical therapy of cataracts by antioxidants. American Journal of Clinical Nutrition, 53, 335S–45S.

    CAS  Google Scholar 

  58. Bruce, G.E., Kinoshita, J. and Horowitz, J. (1990) Nutritional factors in cataract. Annual Reviews of Nutrition, 10, 233–54.

    Article  Google Scholar 

  59. Taylor, A. (1989) Associations between nutrition and cataract. Nutrition Reviews, 47, 225–34.

    Article  CAS  Google Scholar 

  60. Knect, P., Heliövaara, M., Rissanen, A., et al. (1992) Serum antioxidant vitamins and risk of cataract. British Medical Journal, 305, 1392–4.

    Article  Google Scholar 

  61. Sperduto, R.D. (1993) The Linxian cataract studies, two nutrition intervention trials. Archives of Ophthalmology, 111, 1246–53.

    Article  CAS  Google Scholar 

  62. Money, D.F.L. (1970) Vitamin E and selenium deficiencies and their possible aetiological role in the sudden death in infants syndrome. New Zealand Medical Journal, 71, 32–4.

    CAS  Google Scholar 

  63. Money, D.F.L. (1978) Vitamin E, selenium, iron and vitamin A content of livers from sudden infant death syndrome cases and control children: interrelationships and possible significance. New Zealand Journal of Science, 21, 41–4.

    CAS  Google Scholar 

  64. Dolamore, B.A., Sluis, K.B., McGrouter, J.C., et al. (1990) Low selenium and infant death in Christchurch. Proceedings of the Nutrition Society of New Zealand, 15, 181–6.

    Google Scholar 

  65. Rhead, W.J., Cary, E.E., Allaway, W.H., et al. (1972) The vitamin E and selenium status of infants and the sudden infant death syndrome. Bioinorganic Chemistry, 1, 289–95.

    Article  Google Scholar 

  66. Oldfield, J. (1991) Some implications of selenium for human health. Nutrition Today, 26, 6–11.

    Article  Google Scholar 

  67. McGlashan, N.D. and Cook, S. (1992) Selenium deficiency and crib death in Tasmania, in Fifth International Symposium on Selenium in Biology and Medicine, Abstracts, Vanderbilt University School of Medicine, Nashville, TN, p. 142.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Reilly, C. (1996). Selenium in health and disease IV. In: Selenium in Food and Health. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6494-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6494-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6496-3

  • Online ISBN: 978-1-4757-6494-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics