Abstract
The development of in vitro culture systems and cell separation methods has provoked increasing interest in understanding the role of RES accessory cells (AC) in immune induction. As the relevant technology was improved, AC were found to be important in every immune function assayed, such as antibody production in vitro (Mosier, 1969), killer cell induction (Wagner et al., 1972), mixed leukocyte reaction (MLR) (Greineder and Rosenthal, 1975), T-cell proliferation (Rosenwasser and Rosenthal, 1978), etc. Apparent exceptions early on (Diener et al., 1970) were almost certainly reflections of the different types and numbers of AC required for various responses, and also of the inefficiency of AC depletion by conventional adherence procedures which are usually only maintained for the depletion of classical macrophages. Accordingly we were not surprised that T-cell help in vitro required macrophages (Erb and Feldmann, 1975a) .
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References
Andersson, J. O., Gronvik, K. O., Larsson, E. L., and Coutinho, A., 1979, Studies on T lymphocyte activation. I. Requirements for an Ia bearing accessory cell in Con A induced T cell proliferation, Eur. J. Immunol. 9:581.
Cantor, H., and Gershon, R. K., 1979, Immunological circuits: Cellular composition, Fed. Proc. 38:2058.
Cowing, C., Schwartz, B. D., and Dickler, H. B., 1978, Macrophage Ia antigens. I. Macrophage populations differ in their expression of Ia antigens, J. Immunol. 120:378.
Diener, E., Shortman, K., and Russel, P., 1970, Induction of immunity and tolerance in vitro in the absence of phagocytic cells, Nature (London) 225:731.
Drexhage, H. A., Mulliuk, H., de Groot, J., Clarke, J., and Balfour, B. M., 1979, A study of cells present in peripheral lymph of pigs with special reference to a type of cell resembling the Langerhans cell, Cell Tissue Res. 202:407.
Erb, P., 1980, Analysis of the in vitro immune response to insulin. 1. Primary induction of insulin specific T helper cells and characterization of the genetic control of the helper cell response to bovine and nrocine insulin, Immunol. 40:385.
Erb, P., and Feldmann, M., 1975a, Role of macrophages in the in vitro induction of T helper cells,Nature (London) 254:352.
Erb, P., and Feldmann, M., 1975b, The role of macrophages in the generation of T helper cells. II. The genetic control of macrophages—T cell interaction of helper cell induction with soluble antigens, J. Exp. Med. 142:460.
Erb, P., Feldmann, M., and Hogg, N., 1976, Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigen, Eur. J. Immunol. 6:365.
Erb, P., Meier, B., and Feldmann, M., 1979a, Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product?, J. Immunol. 122:1916.
Erb, P., Meier, B., Matsunaga, T., and Feldmann, M., 1979b, Nature of T cell macrophage interaction in helper cell induction in vitro. II. Two stages of T helper cell differentiation analyzed in irradiation and allophenic chimeras, J. Exp. Med. 149:686.
Erb, P., Vogt, P., Matsunaga, T., Rosenthal, A., and Feldmann, M., 1980, Nature of T cell—macrophage interaction in helper cell induction in vitro. III. Responsiveness of T cells differentiating in irradiation or allophenic chimeras depends on the genotype of the host, J. Immunol. 124:2656.
Erb, P., Vogt, P., Cecka, M., and Feldmann, M., 1981, Activation of T cells by I region products released by macrophages, in: Lymphokine Reports (E. Pick, ed.), p. 125, Vol. 2, Academic Press, New York.
Feldmann, M., and Palmer, J., 1971, The requirement for macrophages in the secondary immune response to antigens of small and large size in vitro, Immunology 21:685.
Feldmann, M., Erb, P., and Kontiainen, S., 1975, Cell collaboration between T and B lymphocytes and macrophages in antibody production, in: Lymphocytes and Cell Interactions (R. C. Williams, ed.), pp. 1–22, Raven Press, New York.
Feldmann, M., Rosenthal, A. S., and Erb, P., 1979, Macrophage—lymphocyte interactions in immune induction, Int. Rev. Cytol. 60:149.
Feldmann, M., Sunshine, G. H., and Katz, D. R., 1984, RES-Leucocyte Interactions, in: The Reticuloendothelial System, Vol. 7A: Physiology (S. M. Reichard and J. P. Filkins, eds.), pp. 267–288. Plenum Press.
Gery, I., Gershon, R. K., and Waksman, B. M., 1972, Potentiation of T lymphocyte responses to mitogens, J. Exp. Med. 136:128.
Gorczynski, R. M., 1977, Role of macrophage-derived factors in the generation of cytotoxic and antibody responses, Scand. J. Immunol. 6:665–674.
Greineder, D. K., and Rosenthal, A. S., 1975, Macrophage activation of allogeneic lymphocyte proliferation in the guinea pig mixed leukocyte culture, J. Immunol. 114:154.
Herzenberg, L. A., Black, S. J., and Herzenberg, L. A., 1980, Regulatory circuits and antibody responses, Eur. J. Immunol. 10:1.
Humphrey, J. H., and Grennan, D., 1981, Different macrophage populations distinguished by means of fluorescent polysaccharides: Recognition and properties of marginal zone macrophages, Eur. J. Immunol. 11:221.
Inaba, K., Nabane, K., and Muramatsu, S., 1981, Cellular synergy in the manifestation of accessory cell activity for in vitro antibody responses, J. Immunol. 127:452.
Klaus, G. G. B., Humphrey, H. J., Kunkl, A., and Dongworth, D. W., 1980, The follicular dendritic cell: Its role in antigen presentation and in the generation of immunological memory, Immunol. Rev. 53:3.
Klein, J., Juretic, A., Baxevanis, C. N., and Nagy, Z. A., 1981, The traditional and a new version of the mouse H-2 complex, Nature (London) 291:455.
Larsson, E. L., Coutinhu, A., and Carlos-Martinez, A., 1980, A suggested mechanism for T lymphocyte activation: Implications of the acquisition of functional reactivities, Immunol. Rev. 51:61.
Mitchison, N. A., 1969, The immunogenic capacity of antigen taken up by peritoneal exudate cells, Immunology 16:1.
Mosier, D. E., 1969, Cell interactions in the primary immune response in vitro: a requirement for specific cell clusters, J. Exp. Med, 129:351.
Nossal, G. J. V., and Ada, G. L., 1971, Antigens, Lymphoid Cells, and the Immune Response, Academic Press, New York.
Paetkau, V., Shaw, J., Mills, G., and Caplan, B., 1980, Cellular origins and targets of co-stimulator (IL2), Immunol. Rev. 51:157.
Pierce, C. W., Kapp, J., and Benacerraf, B., 1976, Regulation by the H-2 gene complex of macrophage lymphoid cell interactions in secondary antibody responses in vitro, J. Exp. Med. 144:371.
Puri, J., and Lonai, P., 1980, Mechanism of antigen binding by T cells: H-2 (IA) restricted binding of antigen plus Ia by helper cells, Eur. J. Immunol. 10:273.
Raff, H. Y., Picher, L. J., and Stobo, J. D., 1980, Macrophage heterogeneity in man, J. Exp. Med. 152:581.
Rosenstreich, D. L., and Mizel, S. B., 1979, Signal requirements for T lymphocyte activation, J. Immunol. 22:1749.
Rosenthal, A. S., and Shevach, E. M., 1973, Function of macrophages in antigen recognition by guinea pig T lymphocytes, J. Exp. Med. 138:1194.
Rosenwasser, L. J., and Rosenthal, A. S., 1978, Adherent cell function in murine T lymphocyte recognition, I. Macrophage-dependent T cell proliferative assay in the mouse, J. Immunol. 120:1991.
Scher, M. G., Beller, D. I., and Unanue, E. R., 1980, Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages, J. Exp. Med. 152:1684.
Schreier, M. H., and Tees, R., 1980, Clonal induction of helper T cells: Conversion of specific signals into non-specific signals, Int. Arch. Allergy Appl. Immunol. 61:227.
Schreier, M. H., Iscove, N. N., Tees, R., Awden, L., and von Boehmer, H., 1980, Clones of killer and helper T cells: Growth requirements, specificity and relation of function in long term culture, Immunol. Rev. 51:315.
Schreier, M. H., Tees, R., and Nordin, A., 1982, Establishment and characterization of helper T cell clones: Their function, heterogeneity and effect on the B cell responses to particulate, soluble and T independent antigens, in Lymphokines, Vol. 5 (M. Feldmann and M. H. Schreir, eds.), pp. 443–465. Academic Press, New York.
Sheagren, J. N., Simon, H. B., Tuazon, C. U., and Mehrotra, P. P., 1975, Cell mediated immunity in vitro, in: Monoclonal Phagocytes (R. van Furth, ed.), Blackwell, Oxford.
Smith, K. A., 1980, T cell growth factor, Immunol. Rev. 51:337.
Sprent, J., 1978, Role of H-2 gene products in the function of T helper cells from normal and chimeric mice measured in vivo, Immunol. Rev. 42:108.
Sprent, J., 1978, Restricted helper function of F1—parent bone marrow chimeras controlled by K end of H-2 complex, J. Exp. Med. 147:1838.
Sprent, J., 1980, Blocking T cell function in vivo with anti Ia antibody, J. Exp. Med. 152:996.
Sredni, B., Tse, H. Y., and Schwartz, R. H., 1980, Alloreactivity of an antigen specific T cell clone, Nature (London) 283:581.
Steinman, R. M., and Cohn, Z. A., 1973, Identification of a novel cell type in the peripheral lymphoid organs of mice, J. Exp. Med. 137:1142.
Stingl, G., Tamaki, K., and Katz, S. I., 1980, Origin and function of epidermal Langerhans cells, Immunol. Rev. 53:149.
Sunshine, G. H., Katz, D. R., and Feldmann, M., 1980, Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control, J. Exp. Med. 152:1817.
Sunshine, G. H., Katz, D. R., and Czitrom, A. A., 1982, Heterogeneity of accessory cells in the murine mixed leucocyte response, Eur. J. Immunol. 12:9.
Veerman, A. J., 1974, On the interdigitating cells in the thymus dependent use of the rat spleen: A relation between the mononuclear phagocyte system and T lymphocytes, Cell Tissue Res. 148:247.
Vogt, P., Erb, P., Keller, B., and Feldmann, M., 1980, Nature of macrophage T cell interaction in secondary helper cell generation in vitro: Genetic restriction of macrophage—T cell interaction which also determines T—B genetic restriction, Eur. J. Immunol. 11:377.
Von Boehmer, H., Hans, W., and Jerne, N. K., 1978, MHC linked immune responsiveness is acquired by lymphocykes of low responder mice differentiating in the thymus of high responder mice, Proc. Natl. Acad. Sci. USA 75:2439.
Wagner, H., Feldman, M., Boyle, W., and Scrader, J. W., 1972, Cell mediated immune responses in vitro. III. The requirement for macrophages in cytotoxic reactions against cell bound and subcellular alloantigens, J. Exp. Med. 136:33.
Wagner, H., Hardt, C., Heeg, K., Pfizenmaier, K., Solbach, W., Bartlett, R., Stockingher, H., and Rollinghoff, M., 1980, T—T interactions during cytotoxic T lymphocyte responses: T cell derived helper factor (interleukin-2) as a probe to analyse CTL responsiveness and thymic maturation of CTL progenitors, Immunol. Rev. 51:215.
Watson, J. D., 1979, Continuous proliferation of murine antigen specific helper T lymphocytes in culture, J. Exp. Med. 150:1510.
Woody, J., Zvaifler, N., Rees, A., Ahmed, A., Hartzman, R., Strong, M., Howie, S., Kantor, F., and Feldmann, M., 1979, Human and mouse specific T cell helper factors assayed in vivo and in vitro: implications for human Ir genes, Transplant Proc. 11:382.
Zinkernagel, R. M., Althage, A., Waterfield, E., Kindred, B., Welsh, R. M., Callahan, G., and Pincett, P., 1980, Restriction specificities, alloreactivity and allotolerance expressed by T cells from nude mice reconstituted with H-2 compatible or incompatible thymus grafts, J. Exp. Med. 151:376.
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Katz, D.R., Sunshine, G.H., Feldmann, M., Erb, P. (1984). Role of the Reticuloendothelial System in T-Helper Cell Induction. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_8
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